| Literature DB >> 18376059 |
Patrícia Natália Oliveira Silva1, Carolina Oliveira Gigek, Mariana Ferreira Leal, Paulo Henrique Ferreira Bertolucci, Roger Willian de Labio, Spencer Luiz Marques Payão, Marília de Arruda Cardoso Smith.
Abstract
Longevity related genes were investigated concerning promoter methylation. SIRT3, SMARCA5, HTERT and CDH1 promoters were analyzed in peripheral blood in relation to gender, age and Alzheimer's disease (AD). Methylation Specific PCR assay (MSP) was used. There were no significant differences in methylation frequencies of SIRT3, SMARCA5 and CDH1 among young, elderly and AD groups (p> 0.05), showing no association with aging or AD. On the other hand, HTERT methylation frequency was associated with the aging process, in that AD patients differed from elderly controls (p=0.0086), probably due to telomere and immune dysfunctions involved in AD pathogenesis.Entities:
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Year: 2008 PMID： 18376059 DOI： 10.3233/jad-2008-13207
Source DB: PubMed Journal: J Alzheimers Dis ISSN： 1387-2877 Impact factor: 4.472