Literature DB >> 18375556

Identification of a novel mycobacterial 3-hydroxyacyl-thioester dehydratase, HtdZ (Rv0130), by functional complementation in yeast.

Aner Gurvitz1, J Kalervo Hiltunen, Alexander J Kastaniotis.   

Abstract

We report on the identification of Mycobacterium tuberculosis HtdZ (Rv0130), representing a novel 3-hydroxyacyl-thioester dehydratase. HtdZ was picked up by the functional complementation of Saccharomyces cerevisiae htd2Delta cells lacking the dehydratase of mitochondrial type II fatty acid synthase. Mutant cells expressing HtdZ contained dehydratase activity, recovered their respiratory ability, and partially restored de novo lipoic acid synthesis.

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Year:  2008        PMID： 18375556      PMCID： PMC2395046          DOI： 10.1128/JB.00016-08

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  16 in total

1.  Low-temperature spectral studies on the biosynthesis of cytochromes in Baker's yeast.

Authors:  A LINDENMAYER; R W ESTABROOK
Journal:  Arch Biochem Biophys       Date:  1958-11       Impact factor: 4.013

2.  Mitochondrial acyl carrier protein is involved in lipoic acid synthesis in Saccharomyces cerevisiae.

Authors:  S Brody; C Oh; U Hoja; E Schweizer
Journal:  FEBS Lett       Date:  1997-05-19       Impact factor: 4.124

3.  Changing stereochemistry for a metabolic pathway in vivo. Experiments with the peroxisomal beta-oxidation in yeast.

Authors:  S A Filppula; R T Sormunen; A Hartig; W H Kunau; J K Hiltunen
Journal:  J Biol Chem       Date:  1995-11-17       Impact factor: 5.157

4.  Novel Saccharomyces cerevisiae screen identifies WR99210 analogues that inhibit Mycobacterium tuberculosis dihydrofolate reductase.

Authors:  A'Lissa B Gerum; Jonathan E Ulmer; David P Jacobus; Norman P Jensen; David R Sherman; Carol Hopkins Sibley
Journal:  Antimicrob Agents Chemother       Date:  2002-11       Impact factor: 5.191

5.  Complementation of coq3 mutant yeast by mitochondrial targeting of the Escherichia coli UbiG polypeptide: evidence that UbiG catalyzes both O-methylation steps in ubiquinone biosynthesis.

Authors:  A Y Hsu; W W Poon; J A Shepherd; D C Myles; C F Clarke
Journal:  Biochemistry       Date:  1996-07-30       Impact factor: 3.162

6.  Mutations releasing mitochondrial biogenesis from glucose repression in Saccharomyces cerevisiae.

Authors:  E Böker-Schmitt; S Francisci; R J Schweyen
Journal:  J Bacteriol       Date:  1982-07       Impact factor: 3.490

7.  Htd2p/Yhr067p is a yeast 3-hydroxyacyl-ACP dehydratase essential for mitochondrial function and morphology.

Authors:  Alexander J Kastaniotis; Kaija J Autio; Raija T Sormunen; J Kalervo Hiltunen
Journal:  Mol Microbiol       Date:  2004-09       Impact factor: 3.501

8.  Enzymes converting D-3-hydroxyacyl-CoA to trans-2-enoyl-CoA. Microsomal and peroxisomal isoenzymes in rat liver.

Authors:  L H Malila; K M Siivari; M J Mäkelä; J E Jalonen; P M Latipää; W H Kunau; J K Hiltunen
Journal:  J Biol Chem       Date:  1993-10-15       Impact factor: 5.157

9.  Biosynthesis of lipoic acid: characterization of the lipoic acid auxotrophs Escherichia coli W1485-lip2 and JRG33-lip9.

Authors:  M A Hayden; I Y Huang; G Iliopoulos; M Orozco; G W Ashley
Journal:  Biochemistry       Date:  1993-04-13       Impact factor: 3.162

10.  Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.

Authors:  S T Cole; R Brosch; J Parkhill; T Garnier; C Churcher; D Harris; S V Gordon; K Eiglmeier; S Gas; C E Barry; F Tekaia; K Badcock; D Basham; D Brown; T Chillingworth; R Connor; R Davies; K Devlin; T Feltwell; S Gentles; N Hamlin; S Holroyd; T Hornsby; K Jagels; A Krogh; J McLean; S Moule; L Murphy; K Oliver; J Osborne; M A Quail; M A Rajandream; J Rogers; S Rutter; K Seeger; J Skelton; R Squares; S Squares; J E Sulston; K Taylor; S Whitehead; B G Barrell
Journal:  Nature       Date:  1998-06-11       Impact factor: 49.962
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  6 in total

1.  Revisiting the assignment of Rv0241c to fatty acid synthase type II of Mycobacterium tuberculosis.

Authors:  Emmanuelle Sacco; Nawel Slama; Kristina Bäckbro; Tanya Parish; Françoise Laval; Mamadou Daffé; Nathalie Eynard; Annaik Quémard
Journal:  J Bacteriol       Date:  2010-05-28       Impact factor: 3.490

2.  Heterologous expression of mycobacterial proteins in Saccharomyces cerevisiae reveals two physiologically functional 3-hydroxyacyl-thioester dehydratases, HtdX and HtdY, in addition to HadABC and HtdZ.

Authors:  Aner Gurvitz; J Kalervo Hiltunen; Alexander J Kastaniotis
Journal:  J Bacteriol       Date:  2009-01-09       Impact factor: 3.490

3.  The Mycobacterium tuberculosis relBE toxin:antitoxin genes are stress-responsive modules that regulate growth through translation inhibition.

Authors:  Shaleen B Korch; Vandana Malhotra; Heidi Contreras; Josephine E Clark-Curtiss
Journal:  J Microbiol       Date:  2015-10-28       Impact factor: 3.422

4.  Function of heterologous Mycobacterium tuberculosis InhA, a type 2 fatty acid synthase enzyme involved in extending C20 fatty acids to C60-to-C90 mycolic acids, during de novo lipoic acid synthesis in Saccharomyces cerevisiae.

Authors:  Aner Gurvitz; J Kalervo Hiltunen; Alexander J Kastaniotis
Journal:  Appl Environ Microbiol       Date:  2008-06-13       Impact factor: 4.792

5.  The essential mycobacterial genes, fabG1 and fabG4, encode 3-oxoacyl-thioester reductases that are functional in yeast mitochondrial fatty acid synthase type 2.

Authors:  Aner Gurvitz
Journal:  Mol Genet Genomics       Date:  2009-08-14       Impact factor: 3.291

6.  Caenorhabditis elegans F09E10.3 encodes a putative 3-oxoacyl-thioester reductase of mitochondrial type 2 fatty acid synthase FASII that is functional in yeast.

Authors:  Aner Gurvitz
Journal:  J Biomed Biotechnol       Date:  2009-09-07
  6 in total

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