Literature DB >> 18375358

Advances in experimental and translational research in the treatment of hepatocellular carcinoma.

Travis Kidner1, Menghua Dai, Prasad S Adusumilli, Yuman Fong.   

Abstract

Hepatocellular cancer (HCC) is the fifth-leading cause of cancer and the third-leading cause of cancer related deaths world-wide. Current treatment options are limited, as HCC has been shown to be a highly resistant type of cancer to most current treatment modalities. Novel approaches are being explored in the fields of gene therapy, viral oncolytics, radioembolization, and several new biologic therapies. This article summarizes these recent clinical findings and discusses what role they will have in the future treatment of HCC.

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Year:  2008        PMID: 18375358      PMCID: PMC3269813          DOI: 10.1016/j.soc.2008.01.002

Source DB:  PubMed          Journal:  Surg Oncol Clin N Am        ISSN: 1055-3207            Impact factor:   3.495


  59 in total

Review 1.  Hepatocellular carcinoma: the need for progress.

Authors:  Melanie B Thomas; Andrew X Zhu
Journal:  J Clin Oncol       Date:  2005-05-01       Impact factor: 44.544

Review 2.  Opportunities for targeted therapies in hepatocellular carcinoma.

Authors:  Melanie B Thomas; James L Abbruzzese
Journal:  J Clin Oncol       Date:  2005-11-01       Impact factor: 44.544

3.  Phase II study of Erlotinib (OSI-774) in patients with advanced hepatocellular cancer.

Authors:  Philip A Philip; Michelle R Mahoney; Cristine Allmer; James Thomas; Henry C Pitot; George Kim; Ross C Donehower; Tom Fitch; Joel Picus; Charles Erlichman
Journal:  J Clin Oncol       Date:  2005-09-20       Impact factor: 44.544

Review 4.  Epidemiology of hepatocellular carcinoma.

Authors:  F Xavier Bosch; Josepa Ribes; Ramon Cléries; Mireia Díaz
Journal:  Clin Liver Dis       Date:  2005-05       Impact factor: 6.126

5.  Global cancer statistics, 2002.

Authors:  D Max Parkin; Freddie Bray; J Ferlay; Paola Pisani
Journal:  CA Cancer J Clin       Date:  2005 Mar-Apr       Impact factor: 508.702

6.  Both antiangiogenesis- and angiogenesis-independent effects are responsible for hepatocellular carcinoma growth arrest by tyrosine kinase inhibitor PTK787/ZK222584.

Authors:  Yuqing Liu; Ronnie T Poon; Qinyu Li; Tsz Wai Kok; Cecilia Lau; Sheung Tat Fan
Journal:  Cancer Res       Date:  2005-05-01       Impact factor: 12.701

7.  Prolonged survival of mice with multiple liver metastases of human colon cancer by intravenous administration of replicable E1B-55K-deleted adenovirus with E1A expressed by CEA promoter.

Authors:  Tamotsu Sagawa; Minoru Takahashi; Tsutomu Sato; Yasushi Sato; Yue Lu; Tetsuya Sumiyoshi; Yasuyuki Yamada; Satoshi Iyama; Junki Fukaura; Katsunori Sasaki; Hirofumi Hamada; Koji Miyanishi; Tetsuji Takayama; Junji Kato; Yoshiro Niitsu
Journal:  Mol Ther       Date:  2004-12       Impact factor: 11.454

8.  Prophylactic alpha interferon treatment increases the therapeutic index of oncolytic vesicular stomatitis virus virotherapy for advanced hepatocellular carcinoma in immune-competent rats.

Authors:  Katsunori Shinozaki; Oliver Ebert; Arief Suriawinata; Swan N Thung; Savio L C Woo
Journal:  J Virol       Date:  2005-11       Impact factor: 5.103

9.  Oncolytic recombinant herpes simplex virus for treatment of orthotopic liver tumors in nude mice.

Authors:  Young Sik Chung; Shin-Ichi Miyatake; Akiko Miyamoto; Yoshiharu Miyamoto; Takehiko Dohi; Nobuhiko Tanigawa
Journal:  Int J Oncol       Date:  2006-04       Impact factor: 5.650

Review 10.  ZD6474--a novel inhibitor of VEGFR and EGFR tyrosine kinase activity.

Authors:  A J Ryan; S R Wedge
Journal:  Br J Cancer       Date:  2005-06       Impact factor: 7.640

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  2 in total

1.  An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers.

Authors:  Terence K Lee; Saravana R K Murthy; Niamh X Cawley; Savita Dhanvantari; Stephen M Hewitt; Hong Lou; Tracy Lau; Stephanie Ma; Thanh Huynh; Robert A Wesley; Irene O Ng; Karel Pacak; Ronnie T Poon; Y Peng Loh
Journal:  J Clin Invest       Date:  2011-03       Impact factor: 14.808

2.  Evaluation of miR-122-regulated suicide gene therapy for hepatocellular carcinoma in an orthotopic mouse model.

Authors:  Gang Wang; Xiaoyan Dong; Wenhong Tian; Yue Lu; Jianyan Hu; Yunfan Liu; Jie Yuchi; Xiaobing Wu
Journal:  Chin J Cancer Res       Date:  2013-12       Impact factor: 5.087

  2 in total

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