BACKGROUND: Although the role of cytokines in the development of Hashimoto's thyroiditis has already been established, its pathogenesis has not yet been clearly elucidated. The aim of our study was to investigate serum transforming growth factor-beta1 (TGF-beta1) levels in patients with Hashimoto's thyroiditis as well as the effect of achieving euthyroidism by levothyroxine replacement on TGF-beta1 levels. METHODS: Twenty nine female, newly diagnosed hypothyroid Hashimoto's thyroiditis patients (16 overt, 13 subclinical hypothyroid) and 25 age- and sex-matched healthy controls were enrolled in the study. RESULTS: Serum TGF-beta1 levels were lower in the Hashimoto's thyroiditis group when compared with control cases. Although significant differences were noted in lipid levels and in anthropometric measurements following levothyroxine replacement, serum TGF-beta1 levels remained unchanged. CONCLUSIONS: Our data suggest that altered TGF-beta1 levels are associated with the presence of Hashimoto's thyroiditis, not with the treatment of thyroid dysfunction. Autoimmunity may have been triggered as a result of decreased immunosuppressive effect induced by depressed TGF-beta1 levels in patients with Hashimoto's thyroiditis.
BACKGROUND: Although the role of cytokines in the development of Hashimoto's thyroiditis has already been established, its pathogenesis has not yet been clearly elucidated. The aim of our study was to investigate serum transforming growth factor-beta1 (TGF-beta1) levels in patients with Hashimoto's thyroiditis as well as the effect of achieving euthyroidism by levothyroxine replacement on TGF-beta1 levels. METHODS: Twenty nine female, newly diagnosed hypothyroid Hashimoto's thyroiditispatients (16 overt, 13 subclinical hypothyroid) and 25 age- and sex-matched healthy controls were enrolled in the study. RESULTS: Serum TGF-beta1 levels were lower in the Hashimoto's thyroiditis group when compared with control cases. Although significant differences were noted in lipid levels and in anthropometric measurements following levothyroxine replacement, serum TGF-beta1 levels remained unchanged. CONCLUSIONS: Our data suggest that altered TGF-beta1 levels are associated with the presence of Hashimoto's thyroiditis, not with the treatment of thyroid dysfunction. Autoimmunity may have been triggered as a result of decreased immunosuppressive effect induced by depressedTGF-beta1 levels in patients with Hashimoto's thyroiditis.
Authors: Pablo Cisternas; Antoine Louveau; Susan M Bueno; Alexis M Kalergis; Hélène Boudin; Claudia A Riedel Journal: Mol Neurobiol Date: 2015-12-19 Impact factor: 5.590
Authors: Danilo B Höfling; Maria Cristina Chavantes; Adriana G Juliano; Giovanni G Cerri; Meyer Knobel; Elisabeth M Yoshimura; Maria Cristina Chammas Journal: Lasers Med Sci Date: 2012-06-21 Impact factor: 3.161
Authors: Danilo Bianchini Höfling; Maria Cristina Chavantes; Adriana G Juliano; Giovanni G Cerri; Meyer Knobel; Elisabeth M Yoshimura; Maria Cristina Chammas Journal: ISRN Endocrinol Date: 2012-12-17