| Literature DB >> 18375198 |
Sara Santambrogio1, Angela Cattaneo, Ilenia Bernascone, Thomas Schwend, Luca Jovine, Angela Bachi, Luca Rampoldi.
Abstract
Uromodulin (or Tamm-Horsfall protein) is the most abundant protein in human urine under physiological conditions. Little is known about the molecular mechanism of uromodulin secretion. By extensive Mass Spectrometry analyses we mapped the C-termini of human and murine urinary proteins demonstrating that urinary uromodulin is generated by a conserved C-terminal proteolytic cleavage and retains its entire ZP domain.Entities:
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Year: 2008 PMID： 18375198 DOI： 10.1016/j.bbrc.2008.03.099
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575