Literature DB >> 18375122

Synthesis and antimicrobial properties of monensin A esters.

Adam Huczyński1, Joanna Stefańska, Piotr Przybylski, Bogumil Brzezinski, Franz Bartl.   

Abstract

The esters (2-10) of the ionophore antibiotic Monensin (1) were synthesized by four different methods, which are discussed in detail. These new esters were characterized by various spectroscopic techniques and subsequently tested in the face of their antimicrobial properties. Three derivatives (3, 8 and 10) showed activity against Gram-positive bacteria. Additionally derivative (10) exhibited a relatively low antifungal activity against Candida in contrast to Monensin A.

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Year:  2008        PMID： 18375122     DOI： 10.1016/j.bmcl.2008.03.038

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Siloxyl ether functionalized resins for chemoselective enrichment of carboxylic acids.

Authors:  Darci J Trader; Erin E Carlson
Journal:  Org Lett       Date:  2011-09-29       Impact factor: 6.005

2.  Jacobsen catalyst as a cytochrome P450 biomimetic model for the metabolism of monensin A.

Authors:  Bruno Alves Rocha; Anderson Rodrigo Moraes de Oliveira; Murilo Pazin; Daniel Junqueira Dorta; Andresa Piacezzi Nascimento Rodrigues; Andresa Aparecida Berretta; Ana Paula Ferranti Peti; Luiz Alberto Beraldo de Moraes; Norberto Peporine Lopes; Stanislav Pospíšil; Paul Jonathan Gates; Marilda das Dores Assis
Journal:  Biomed Res Int       Date:  2014-05-28       Impact factor: 3.411

Review 3.  Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements.

Authors:  Daniel Aowicki; Adam Huczyński
Journal:  Biomed Res Int       Date:  2013-02-13       Impact factor: 3.411

Review 4.  Structures and properties of naturally occurring polyether antibiotics.

Authors:  Jacek Rutkowski; Bogumil Brzezinski
Journal:  Biomed Res Int       Date:  2013-03-17       Impact factor: 3.411

5.  Autophagy Inhibition with Monensin Enhances Cell Cycle Arrest and Apoptosis Induced by mTOR or Epidermal Growth Factor Receptor Inhibitors in Lung Cancer Cells.

Authors:  Hyeong Sim Choi; Eun-Hui Jeong; Tae-Gul Lee; Seo Yun Kim; Hye-Ryoun Kim; Cheol Hyeon Kim
Journal:  Tuberc Respir Dis (Seoul)       Date:  2013-07-31

6.  In vitro activity of salinomycin and monensin derivatives against Trypanosoma brucei.

Authors:  Dietmar Steverding; Michał Antoszczak; Adam Huczyński
Journal:  Parasit Vectors       Date:  2016-07-25       Impact factor: 3.876
  6 in total

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