| Literature DB >> 18375120 |
Naoki Teno1, Osamu Irie, Takahiro Miyake, Keigo Gohda, Miyuki Horiuchi, Sachiyo Tada, Kazuhiko Nonomura, Motohiko Kometani, Genji Iwasaki, Claudia Betschart.
Abstract
Cyano pyrimidine acetylene and cyano pyrimidine t-amine, which belong to a new chemical class, were prepared and tested for inhibitory activities against cathepsin K and the highly homologous cathepsins L and S. The use of novel chemotypes in the development of cathepsin K inhibitors has been demonstrated by derivatives of compounds 1 and 8.Entities:
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Year: 2008 PMID： 18375120 DOI： 10.1016/j.bmcl.2008.03.036
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823