| Literature DB >> 18375022 |
El-Sayed Moustafa Ibrahim1, A K M Shofiqur Rahman, Rie Isoda, Kouji Umeda, Nguyen Van Sa, Yoshikatsu Kodama.
Abstract
We prepared anti-Candida albicans antibody in chicken egg yolk (anti-CA IgY) and investigated its in vitro and in vivo effectiveness. Anti-CA IgY significantly reduced the adherence capacity of C. albicans to FaDu cells (human pharynx carcinoma cells) in a dose-dependent manner. The protective efficacy of anti-CA IgY was investigated in experimentally induced oral candidiasis in immunosuppressed mice. Oral administration of anti-CA IgY significantly reduced the number of C. albicans and the scores of the tongue lesions. Moreover, anti-CA IgY reduced the colonization of C. albicans in mice organs. These results indicate that anti-CA IgY has a protective effect against the oral candidiasis of experimentally infected mice and reduces the dissemination of C. albicans. Putting together, these results indicate that anti-CA IgY is effective against C. albicans. This effect might be due to the blocking of the binding of C. albicans to the host cells. Therefore, anti-CA IgY might be considered as a prophylactic immunotherapy or possibly an adjunctive antifungal therapy.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18375022 DOI： 10.1016/j.vaccine.2008.02.046
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641