Literature DB >> 18374658

Crucial roles of D-type cyclins in the early stage of adipocyte differentiation.

Tomoaki Hishida1, Kumiko Naito, Shigehiro Osada, Makoto Nishizuka, Masayoshi Imagawa.   

Abstract

Cyclin D2 was isolated as one of the genes expressed early in adipogenesis. The expression of cyclin D2 increased temporarily early on and then again late in the differentiation process. The expression of cyclin D1 and cyclin D3, the other D-type cyclins, was also transiently induced early during adipocyte differentiation. RNAi (RNA interference)-mediated knockdown of cyclin D1, D2, or D3 inhibited the differentiation of 3T3-L1 cells into lipid-laden adipocytes. Moreover, the knockdown of cyclin D1 or D3 significantly inhibited mitotic clonal expansion (MCE), while silencing of the cyclin D2 gene had a milder effect on MCE. Each of the D-type cyclins seems to play a crucial role in adipocyte differentiation by regulating MCE.

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Year:  2008        PMID： 18374658     DOI： 10.1016/j.bbrc.2008.03.091

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

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  8 in total

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