Literature DB >> 18374570

Synthesis of 4'-modified noraristeromycins to clarify the effect of the 4'-hydroxyl groups for inhibitory activity against S-adenosyl-L-homocysteine hydrolase.

Takayuki Ando1, Kenji Kojima, Praveen Chahota, Atsushi Kozaki, Nikalje D Milind, Yukio Kitade.   

Abstract

4'-Modified noraristeromycin (NAM) analogs, 4'-sulfo-, 4'-sulfamoy, 4'-azido and 4'-amino-NAM, were systematically synthesized. The inhibitory activities of these analogs and related compounds against Plasmodium falciparum and human S-adenosyl-L-homocysteine hydrolase were investigated.

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Year:  2008        PMID： 18374570     DOI： 10.1016/j.bmcl.2008.03.029

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  An efficient synthesis of the 4'-epimer of 2-fluoronoraristeromycin.

Authors:  Quachel Bazile; Tesfaye Serbessa; Junyan Zhong
Journal:  Tetrahedron Lett       Date:  2012-01-20       Impact factor: 2.415

2.  Predicting target-ligand interactions with graph convolutional networks for interpretable pharmaceutical discovery.

Authors:  Paola Ruiz Puentes; Laura Rueda-Gensini; Natalia Valderrama; Isabela Hernández; Cristina González; Laura Daza; Carolina Muñoz-Camargo; Juan C Cruz; Pablo Arbeláez
Journal:  Sci Rep       Date:  2022-05-19       Impact factor: 4.996

3.  Human S-adenosylhomocysteine hydrolase: common gene sequence variation and functional genomic characterization.

Authors:  Qiping Feng; Mani Keshtgarpour; Linda L Pelleymounter; Irene Moon; Krishna R Kalari; Bruce W Eckloff; Eric D Wieben; Richard M Weinshilboum
Journal:  J Neurochem       Date:  2009-07-08       Impact factor: 5.372
  3 in total

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