Literature DB >> 18374204

Hepatocellular carcinoma and vitamin K.

Toshihiko Mizuta1, Iwata Ozaki.   

Abstract

On the basis of reports of the antitumor effects of vitamin K on various cancers, we clinically investigated the suppressive effects of vitamin K2 on tumor recurrence after curative treatment for hepatocellular carcinoma (HCC). Our results showed that vitamin K2 administration significantly suppressed HCC recurrence. Our laboratory findings revealed that the inhibitory effect of vitamin K2 against HCC cell growth was generated by suppressing cyclin D1 expression through inhibition of NF-kappaB activation.

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Year:  2008        PMID： 18374204     DOI： 10.1016/S0083-6729(07)00018-0

Source DB:  PubMed          Journal:  Vitam Horm        ISSN： 0083-6729            Impact factor:   3.421


  4 in total

1.  Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells.

Authors:  Asagi Ito; Hitoshi Shirakawa; Naofumi Takumi; Yoshihiko Minegishi; Ai Ohashi; Zakir H Howlader; Yusuke Ohsaki; Toshiro Sato; Tomoko Goto; Michio Komai
Journal:  Lipids Health Dis       Date:  2011-09-13       Impact factor: 3.876

2.  Vitamin K2 and cotylenin A synergistically induce monocytic differentiation and growth arrest along with the suppression of c-MYC expression and induction of cyclin G2 expression in human leukemia HL-60 cells.

Authors:  Yasuhisa Maniwa; Takashi Kasukabe; Shunichi Kumakura
Journal:  Int J Oncol       Date:  2015-06-04       Impact factor: 5.650

3.  Vitamin K1 exerts antiproliferative effects and induces apoptosis in three differently graded human colon cancer cell lines.

Authors:  Antonella Orlando; Michele Linsalata; Valeria Tutino; Benedetta D'Attoma; Maria Notarnicola; Francesco Russo
Journal:  Biomed Res Int       Date:  2015-05-17       Impact factor: 3.411

4.  Role of vitamin K2 in preventing the recurrence of hepatocellular carcinoma after curative treatment: a meta-analysis of randomized controlled trials.

Authors:  Irbaz Bin Riaz; Haris Riaz; Talha Riaz; Sophia Rahman; Muhammad Amir; Maaz B Badshah; Abdul Nafey Kazi
Journal:  BMC Gastroenterol       Date:  2012-11-29       Impact factor: 3.067
  4 in total

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