Literature DB >> 18373338

Solid-phase synthesis of tris-heteroleptic ruthenium(II) complexes and application to acetylcholinesterase inhibition.

Seann P Mulcahy1, Shan Li, Ricarda Korn, Xiulan Xie, Eric Meggers.   

Abstract

A synthetic route with two consecutive coordination chemistry steps on a solid support affords tris-heteroleptic ruthenium(II) polypyridyl complexes with high purity and in good yields. As an application we report the identification of a nanomolar acetylcholinesterase inhibitor from a small ruthenium complex library synthesized on Lanterns.

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Year:  2008        PMID： 18373338     DOI： 10.1021/ic800080b

Source DB:  PubMed          Journal:  Inorg Chem        ISSN： 0020-1669            Impact factor:   5.165


  6 in total

1.  Solid-phase synthesis as a platform for the discovery of new ruthenium complexes for efficient release of photocaged ligands with visible light.

Authors:  Rajgopal Sharma; Jessica D Knoll; Nicholas Ancona; Phillip D Martin; Claudia Turro; Jeremy J Kodanko
Journal:  Inorg Chem       Date:  2015-01-22       Impact factor: 5.165

2.  Catch and Release Photosensitizers: Combining Dual-Action Ruthenium Complexes with Protease Inactivation for Targeting Invasive Cancers.

Authors:  Karan Arora; Mackenzie Herroon; Malik H Al-Afyouni; Nicholas P Toupin; Thomas N Rohrabaugh; Lauren M Loftus; Izabela Podgorski; Claudia Turro; Jeremy J Kodanko
Journal:  J Am Chem Soc       Date:  2018-10-22       Impact factor: 15.419

3.  Strategy for the stereochemical assignment of tris-heteroleptic Ru(II) complexes by NMR spectroscopy.

Authors:  Xiulan Xie; Seann P Mulcahy; Eric Meggers
Journal:  Inorg Chem       Date:  2009-02-02       Impact factor: 5.165

4.  Synthesis, DNA-Binding, Anticancer Evaluation, and Molecular Docking Studies of Bishomoleptic and Trisheteroleptic Ru-Diimine Complexes Bearing 2-(2-Pyridyl)-quinoxaline.

Authors:  Sofia Balou; Athanasios Zarkadoulas; Maria Koukouvitaki; Luciano Marchiò; Eleni K Efthimiadou; Christiana A Mitsopoulou
Journal:  Bioinorg Chem Appl       Date:  2021-05-12       Impact factor: 7.778

5.  Photosensitive Ru(II) Complexes as Inhibitors of the Major Human Drug Metabolizing Enzyme CYP3A4.

Authors:  Nicholas Toupin; Sean J Steinke; Sandeep Nadella; Ao Li; Thomas N Rohrabaugh; Eric R Samuels; Claudia Turro; Irina F Sevrioukova; Jeremy J Kodanko
Journal:  J Am Chem Soc       Date:  2021-06-10       Impact factor: 16.383

6.  Structural Isomerism and Enhanced Lipophilicity of Pyrithione Ligands of Organoruthenium(II) Complexes Increase Inhibition on AChE and BuChE.

Authors:  Jerneja Kladnik; Samuel Ristovski; Jakob Kljun; Andrea Defant; Ines Mancini; Kristina Sepčić; Iztok Turel
Journal:  Int J Mol Sci       Date:  2020-08-06       Impact factor: 5.923
  6 in total

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