Literature DB >> 18373337

Isoxazolone based inhibitors of p38 MAP kinases.

Stefan A Laufer1, Simona Margutti.   

Abstract

SAR of N-alkylated isoxazolones as p38 MAP kinase inhibitors was realized. The data herein show the possibility of transferring the SAR study and evaluation from N-1-substituted imidazole to isoxazolones. Optimization of substituent was realized.

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Year:  2008        PMID： 18373337     DOI： 10.1021/jm701343f

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  4 in total

1.  Rosiglitazone inhibits TGF-β 1 induced activation of human Tenon fibroblasts via p38 signal pathway.

Authors:  Yong-Heng Luo; Ping-Bo Ouyang; Jiao Tian; Xiao-Jian Guo; Xuan-Chu Duan
Journal:  PLoS One       Date:  2014-08-21       Impact factor: 3.240

2.  Design, Synthesis and Biological Evaluation of Novel Substituted N,N'-Diaryl ureas as Potent p38 Inhibitors.

Authors:  Dianxi Zhu; Xingzhou Li; Wu Zhong; Dongmei Zhao
Journal:  Molecules       Date:  2015-09-11       Impact factor: 4.411

3.  Access to β-Alkylated γ-Functionalized Ketones via Conjugate Additions to Arylideneisoxazol-5-ones and Mo(CO)6-Mediated Reductive Cascade Reactions.

Authors:  Antonio Macchia; Francesco F Summa; Guglielmo Monaco; Andreas Eitzinger; Armin R Ofial; Antonia Di Mola; Antonio Massa
Journal:  ACS Omega       Date:  2022-03-04

4.  Synthesis, biological evaluation, and molecular modelling studies of potent human neutrophil elastase (HNE) inhibitors.

Authors:  Maria Paola Giovannoni; Igor A Schepetkin; Mark T Quinn; Niccolò Cantini; Letizia Crocetti; Gabriella Guerrini; Antonella Iacovone; Paola Paoli; Patrizia Rossi; Gianluca Bartolucci; Marta Menicatti; Claudia Vergelli
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051
  4 in total

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