Literature DB >> 18373203

Transitioning of children with GH deficiency to adult dosing: changes in body composition.

Vi Thuy Nguyen1, Madhusmita Misra.   

Abstract

As more evidence gathers regarding the beneficial effect of growth hormone replacement therapy (GHRT) on body composition and other parameters in adults with childhood-onset growth hormone deficiency (GHD), questions emerge regarding whether or not GHRT should be discontinued following cessation of statural growth, and the effect of GHRT during the transition period on body composition and related parameters. This review discusses the effect of discontinuation of GHRT following attainment of adult stature, and the treatment and dose effect when GHRT is reinstated. We also review data regarding who should receive GHRT, the criteria for diagnosing persistent GHD, dosing of GHRT and the possibility of a GH 'holiday'.

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Year:  2009        PMID： 18373203     DOI： 10.1007/s11102-008-0101-y

Source DB:  PubMed          Journal:  Pituitary        ISSN： 1386-341X            Impact factor:   4.107


  38 in total

1.  Adolescents with partial growth hormone (GH) deficiency develop alterations of body composition after GH discontinuation and require follow-up.

Authors:  Maithé Tauber; Béatrice Jouret; Audrey Cartault; Nadia Lounis; Michèle Gayrard; Corinne Marcouyeux; Catherine Pienkowski; Isabelle Oliver; Pierre Moulin; Philippe Otal; Francis Joffre; Catherine Arnaud; Pierre Rochiccioli
Journal:  J Clin Endocrinol Metab       Date:  2003-11       Impact factor: 5.958

2.  Discontinuation of growth hormone (GH) treatment: metabolic effects in GH-deficient and GH-sufficient adolescent patients compared with control subjects. Swedish Study Group for Growth Hormone Treatment in Children.

Authors:  G Johannsson; K Albertsson-Wikland; B A Bengtsson
Journal:  J Clin Endocrinol Metab       Date:  1999-12       Impact factor: 5.958

3.  Quality of life in childhood onset growth hormone-deficient patients in the transition phase from childhood to adulthood.

Authors:  Andrea F Attanasio; Elena P Shavrikova; Werner F Blum; Stephen M Shalet
Journal:  J Clin Endocrinol Metab       Date:  2005-05-17       Impact factor: 5.958

4.  Long-term effects of growth hormone (GH) replacement in men with childhood-onset GH deficiency.

Authors:  J C ter Maaten; H de Boer; O Kamp; L Stuurman; E A van der Veen
Journal:  J Clin Endocrinol Metab       Date:  1999-07       Impact factor: 5.958

5.  Retesting young adults with childhood-onset growth hormone (GH) deficiency with GH-releasing-hormone-plus-arginine test.

Authors:  G Aimaretti; C Baffoni; S Bellone; L Di Vito; G Corneli; E Arvat; L Benso; F Camanni; E Ghigo
Journal:  J Clin Endocrinol Metab       Date:  2000-10       Impact factor: 5.958

Review 6.  Determinants of musculoskeletal frailty and the risk of falls in old age.

Authors:  M Runge; G Hunter
Journal:  J Musculoskelet Neuronal Interact       Date:  2006 Apr-Jun       Impact factor: 2.041

Review 7.  Human growth hormone and human aging.

Authors:  E Corpas; S M Harman; M R Blackman
Journal:  Endocr Rev       Date:  1993-02       Impact factor: 19.871

Review 8.  Concepts in the diagnosis of adult growth hormone deficiency.

Authors:  Beverly M K Biller
Journal:  Horm Res       Date:  2007-12-10

9.  The severity of growth hormone deficiency in adults with pituitary disease is related to the degree of hypopituitarism.

Authors:  A A Toogood; C G Beardwell; S M Shalet
Journal:  Clin Endocrinol (Oxf)       Date:  1994-10       Impact factor: 3.478

10.  Attainment of peak bone mass at the lumbar spine, femoral neck and radius in men and women: relative contributions of bone size and volumetric bone mineral density.

Authors:  Yvette M Henry; Diana Fatayerji; Richard Eastell
Journal:  Osteoporos Int       Date:  2004-02-24       Impact factor: 4.507
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  9 in total

Review 1.  Growth hormone treatment in adults with growth hormone deficiency: the transition.

Authors:  M E Molitch
Journal:  J Endocrinol Invest       Date:  2011-01-26       Impact factor: 4.256

Review 2.  Diagnosis and treatment of growth hormone deficiency in adults.

Authors:  Atil Y Kargi; George R Merriam
Journal:  Nat Rev Endocrinol       Date:  2013-04-30       Impact factor: 43.330

3.  A longer interval without GH replacement and female gender are associated with lower bone mineral density in adults with childhood-onset GH deficiency: a KIMS database analysis.

Authors:  Nicholas A Tritos; Amir H Hamrahian; Donna King; Susan L Greenspan; David M Cook; Peter J Jönsson; Michael P Wajnrajch; Maria Koltowska-Häggstrom; Beverly M K Biller
Journal:  Eur J Endocrinol       Date:  2012-06-18       Impact factor: 6.664

Review 4.  Growth hormone deficiency in the transition period: body composition and gonad function.

Authors:  G Balercia; L Giovannini; F Paggi; M Spaziani; N Tahani; M Boscaro; A Lenzi; A Radicioni
Journal:  J Endocrinol Invest       Date:  2011-06-21       Impact factor: 4.256

5.  Contextualized analysis of a needs assessment using the Theoretical Domains Framework: a case example in endocrinology.

Authors:  Patrice Lazure; Robert C Bartel; Beverly M K Biller; Mark E Molitch; Stephen M Rosenthal; Judith L Ross; Brock D Bernsten; Sean M Hayes
Journal:  BMC Health Serv Res       Date:  2014-07-24       Impact factor: 2.655

6.  An audit of the management of childhood-onset growth hormone deficiency during young adulthood in Scotland.

Authors:  M Ahmid; V Fisher; A J Graveling; S McGeoch; E McNeil; J Roach; J S Bevan; L Bath; M Donaldson; G Leese; A Mason; C G Perry; N N Zammitt; S F Ahmed; M G Shaikh
Journal:  Int J Pediatr Endocrinol       Date:  2016-03-16

Review 7.  Childhood-onset growth hormone deficiency and the transition to adulthood: current perspective.

Authors:  M Ahmid; S F Ahmed; M G Shaikh
Journal:  Ther Clin Risk Manag       Date:  2018-11-23       Impact factor: 2.423

Review 8.  Clinical, Diagnostic, and Therapeutic Aspects of Growth Hormone Deficiency During the Transition Period: Review of the Literature.

Authors:  Matteo Spaziani; Chiara Tarantino; Natascia Tahani; Daniele Gianfrilli; Emilia Sbardella; Andrea M Isidori; Andrea Lenzi; Antonio F Radicioni
Journal:  Front Endocrinol (Lausanne)       Date:  2021-02-24       Impact factor: 5.555

Review 9.  Growth hormone deficiency and the transition from pediatric to adult care.

Authors:  Ana Beatriz Winter Tavares; Paulo Ferrez Collett-Solberg
Journal:  J Pediatr (Rio J)       Date:  2021-03-24       Impact factor: 2.990
  9 in total

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