Literature DB >> 18373168

Hepatitis B caused by a hepatitis B surface antigen escape mutant.

Eiji Kajiwara1, Yasuhito Tanaka, Tomoko Ohashi, Kotarou Uchimura, Seizo Sadoshima, Mitsuru Kinjo, Masashi Mizokami.   

Abstract

Amino acid substitutions within the S gene involving the major antigenic a determinant of the hepatitis B virus (HBV) surface antigen (HBsAg) have been detected in cases of failure of immunization against the virus. Our report showed development of clinical hepatitis in presence of antibody to HBsAg in a healthy individual. A single amino acid substitution (G145R) within the a determinant of the HBsAg was determined by sequencing of the isolated HBV strain. Lamivudine treatment efficiently cleared the peripheral HBV DNA, HBsAg, and hepatitis B e antigen. In conclusion, the immune escape mutant in the S gene can cause hepatitis despite pre-existing naturally acquired immunity.

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Year:  2008        PMID： 18373168     DOI： 10.1007/s00535-007-2150-9

Source DB:  PubMed          Journal:  J Gastroenterol        ISSN： 0944-1174            Impact factor:   7.527


  26 in total

1.  Presence of hepatitis B surface antigen mutant G145R DNA in the peripheral blood leukocytes of the family members of an asymptomatic carrier and evidence of its horizontal transmission.

Authors:  Runu Chakravarty; Madhubanti Neogi; Susanta Roychowdhury; Chinmoy Kumar Panda
Journal:  Virus Res       Date:  2002-12       Impact factor: 3.303

2.  Altered antigenicity of 'a' determinant variants of hepatitis B virus.

Authors:  H L Chiou; T S Lee; J Kuo; Y C Mau; M S Ho
Journal:  J Gen Virol       Date:  1997-10       Impact factor: 3.891

3.  Molecular analysis of antigenicity and immunogenicity of a vaccine-induced escape mutant of hepatitis B virus.

Authors:  Toru Shizuma; Kiyoshi Hasegawa; Kayo Ishikawa; Takuma Naritomi; Aiko Iizuka; Naoko Kanai; Miho Ogawa; Nobuyuki Torii; Riho Joh; Naoaki Hayashi
Journal:  J Gastroenterol       Date:  2003       Impact factor: 7.527

4.  Genetic alterations in the S gene of hepatitis B virus in patients with acute hepatitis B, chronic hepatitis B and hepatitis B liver cirrhosis before and after liver transplantation.

Authors:  F Rodriguez-Frias; M Buti; R Jardi; V Vargas; J Quer; M Cotrina; M Martell; R Esteban; J Guardia
Journal:  Liver       Date:  1999-06

5.  Detection of a hepatitis B surface antigen variant emerging in a patient with chronic lymphocytic leukaemia treated with fludarabine.

Authors:  Alexandra Alexopoulou; Spyros P Dourakis; Helen Pandelidaki; Athanasios J Archimandritis; Peter Karayiannis
Journal:  J Med Virol       Date:  2006-08       Impact factor: 2.327

6.  Point mutation in the S gene of hepatitis B virus for a d/y or w/r subtypic change in two blood donors carrying a surface antigen of compound subtype adyr or adwr.

Authors:  H Okamoto; M Imai; F Tsuda; T Tanaka; Y Miyakawa; M Mayumi
Journal:  J Virol       Date:  1987-10       Impact factor: 5.103

7.  A dominant hepatitis B virus population defective in virus secretion because of several S-gene mutations from a patient with fulminant hepatitis.

Authors:  T Kalinina; A Riu; L Fischer; H Will; M Sterneck
Journal:  Hepatology       Date:  2001-08       Impact factor: 17.425

8.  The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response.

Authors:  B Rehermann; C Ferrari; C Pasquinelli; F V Chisari
Journal:  Nat Med       Date:  1996-10       Impact factor: 53.440

9.  Characterization of unusual escape variants of hepatitis B virus isolated from a hepatitis B surface antigen-negative subject.

Authors:  S Grethe; M Monazahian; I Böhme; R Thomssen
Journal:  J Virol       Date:  1998-09       Impact factor: 5.103

Review 10.  Hepatitis B virus immunopathogenesis.

Authors:  F V Chisari; C Ferrari
Journal:  Annu Rev Immunol       Date:  1995       Impact factor: 28.527
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  4 in total

1.  Change in hepatitis B virus large surface antigen variant prevalence 13 years after implementation of a universal vaccination program in China.

Authors:  Tao Bian; Hongxia Yan; Liping Shen; Feng Wang; Shuang Zhang; Yanqiang Cao; Shuo Zhang; Yong Zhang; Shengli Bi
Journal:  J Virol       Date:  2013-09-04       Impact factor: 5.103

2.  Reactivation of hepatitis B with reappearance of hepatitis B surface antigen after chemotherapy and immunosuppression.

Authors:  Tara N Palmore; Neeral L Shah; Rohit Loomba; Brian B Borg; Uri Lopatin; Jordan J Feld; Farooq Khokhar; Glen Lutchman; David E Kleiner; Neal S Young; Richard Childs; A John Barrett; T Jake Liang; Jay H Hoofnagle; Theo Heller
Journal:  Clin Gastroenterol Hepatol       Date:  2009-07-01       Impact factor: 11.382

Review 3.  Hepatitis B Virus Adaptation to the CD8+ T Cell Response: Consequences for Host and Pathogen.

Authors:  Sheila F Lumley; Anna L McNaughton; Paul Klenerman; Katrina A Lythgoe; Philippa C Matthews
Journal:  Front Immunol       Date:  2018-07-16       Impact factor: 7.561

4.  Characterization of Novel Hepatitis B Virus PreS/S-Gene Mutations in a Patient with Occult Hepatitis B Virus Infection.

Authors:  Jianhong Chen; Yan Liu; Jun Zhao; Zhihui Xu; Rongjuan Chen; Lanlan Si; Shanshan Lu; Xiaodong Li; Shuai Wang; Kai Zhang; Jin Li; Juqiang Han; Dongping Xu
Journal:  PLoS One       Date:  2016-05-16       Impact factor: 3.240
  4 in total

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