Role of systemic control of postural muscle hydration under conditions of gravitational unloading.

The purpose of our research was to investigate a role of systemic mechanisms of regulation of hydration in postural muscles of mammals under conditions of gravitational unloading. It was shown that administration of desmopressin in hindlimb suspended rats led to systemic hyperhydration and amelioration of soleus muscle water loss. However in desmopressin administered and unloaded animals the soleus fiber size and soleus dry weight reduction turned out to be non significant.