Literature DB >> 1837174

Novel fold and putative receptor binding site of granulocyte-macrophage colony-stimulating factor.

K Diederichs1, T Boone, P A Karplus.   

Abstract

Granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulates the development of and the cytotoxic activity of white blood cells. Recombinant human GM-CSF has proven useful in the treatment of blood disorders. The structure of GM-CSF, which was determined at 2.4 angstrom resolution by x-ray crystallography, has a novel fold combining a two-stranded antiparallel beta sheet with an open bundle of four alpha helices. Residues implicated in receptor recognition, which are distant in the primary sequence, are on adjacent alpha helices in the folded protein. A working model for the receptor binding site is presented.

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Year:  1991        PMID： 1837174     DOI： 10.1126/science.1837174

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  40 in total

1.  The structure of granulocyte-colony-stimulating factor and its relationship to other growth factors.

Authors:  C P Hill; T D Osslund; D Eisenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-01       Impact factor: 11.205

2.  Mapping the ovine genes encoding IL3, IL4, IL5, and CSF2 to sheep chromosome 5q13-q15 by FISH.

Authors:  R J Hawken; M F Broom; T C van Stijn; J M Lumsden; T E Broad; J F Maddox
Journal:  Mamm Genome       Date:  1996-11       Impact factor: 2.957

Review 3.  Overview of the purification of recombinant proteins.

Authors:  Paul T Wingfield
Journal:  Curr Protoc Protein Sci       Date:  2015-04-01

4.  Monomeric isomers of human interleukin 5 show that 1:1 receptor recruitment is sufficient for function.

Authors:  J Li; R Cook; M L Doyle; P Hensley; D E McNulty; I Chaiken
Journal:  Proc Natl Acad Sci U S A       Date:  1997-06-24       Impact factor: 11.205

5.  Mutagenesis in the C-terminal region of human interleukin 5 reveals a central patch for receptor alpha chain recognition.

Authors:  T Morton; J Li; R Cook; I Chaiken
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-21       Impact factor: 11.205

6.  Homology model of human interferon-alpha 8 and its receptor complex.

Authors:  M H Seto; R N Harkins; M Adler; M Whitlow; W B Church; E Croze
Journal:  Protein Sci       Date:  1995-04       Impact factor: 6.725

7.  Saturation mutagenesis of the human interleukin 6 receptor-binding site: implications for its three-dimensional structure.

Authors:  R Savino; A Lahm; M Giorgio; A Cabibbo; A Tramontano; G Ciliberto
Journal:  Proc Natl Acad Sci U S A       Date:  1993-05-01       Impact factor: 11.205

8.  Role of the C-terminus in the activity, conformation, and stability of interleukin-6.

Authors:  L D Ward; A Hammacher; J G Zhang; J Weinstock; K Yasukawa; C J Morton; R S Norton; R J Simpson
Journal:  Protein Sci       Date:  1993-09       Impact factor: 6.725

9.  Hematopoietic cytokines: similarities and differences in the structures, with implications for receptor binding.

Authors:  A Wlodawer; A Pavlovsky; A Gustchina
Journal:  Protein Sci       Date:  1993-09       Impact factor: 6.725

10.  Structure-function relationships of interleukin-3. An analysis based on the function and binding characteristics of a series of interspecies chimera of gibbon and murine interleukin-3.

Authors:  K Kaushansky; S G Shoemaker; V C Broudy; N L Lin; J V Matous; E M Alderman; J D Aghajanian; P J Szklut; R E VanDyke; M K Pearce
Journal:  J Clin Invest       Date:  1992-11       Impact factor: 14.808
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