Literature DB >> 1837072

Nigrostriatal pathway modulates striatum vulnerability to quinolinic acid.

A Buisson1, V Pateau, M Plotkine, R G Boulu.   

Abstract

This study evaluates the modulation of striatum vulnerability to quinolinic acid (QA) by the nitrostriatal projection. Unilateral lesioning of the substantia nigra with 6-hydroxydopamine markedly reduced the volume of striatal necrosis observed 3 days after local injection of quinolinic acid (150 nmol). This result is consistent with the concept that the nigrostriatal pathway potentiates the vulnerability of striatum to excitotoxic damage.

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Year:  1991        PMID： 1837072     DOI： 10.1016/0304-3940(91)90627-6

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  4 in total

1.  Ciliary neurotrophic factor protects striatal output neurons in an animal model of Huntington disease.

Authors:  K D Anderson; N Panayotatos; T L Corcoran; R M Lindsay; S J Wiegand
Journal:  Proc Natl Acad Sci U S A       Date:  1996-07-09       Impact factor: 11.205

2.  Kynurenic acid leads, dopamine follows: a new case of volume transmission in the brain?

Authors:  H-Q Wu; A Rassoulpour; R Schwarcz
Journal:  J Neural Transm (Vienna)       Date:  2006-08-24       Impact factor: 3.575

3.  Dopamine receptor activation reveals a novel, kynurenate-sensitive component of striatal N-methyl-D-aspartate neurotoxicity.

Authors:  B Poeggeler; A Rassoulpour; H-Q Wu; P Guidetti; R C Roberts; R Schwarcz
Journal:  Neuroscience       Date:  2007-07-16       Impact factor: 3.590

4.  A rat model of striatonigral degeneration generated by simultaneous injection of 6-hydroxydopamine into the medial forebrain bundle and quinolinic acid into the striatum.

Authors:  Hyung Ho Yoon; Yong Hwan Kim; Eun Sil Shin; Sang Ryong Jeon
Journal:  J Korean Med Sci       Date:  2014-11-04       Impact factor: 2.153
  4 in total

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