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Literature DB >> 1837028

Clinical significance of IgG subclasses of Anti-Sm and U1 ribonucleoprotein antibodies in patients with systemic lupus erythematosus and mixed connective tissue disease.

Y Tokano¹, M Yasuma, S Harada, Y Takasaki, H Hashimoto, K Okumura, S Hirose.

Abstract

IgG subclasses of anti-Sm and anti-U1 ribonucleoprotein (U1 RNP) antibodies were determined using a new clone of the anti-IgG2 antibody (HG2-56F). Although the predominance of IgG1 coincided with previous reports, IgG2 anti-Sm and U1 RNP antibodies were detected in numerous patients. IgG3 anti-Sm antibody significantly correlates with joint involvement and a high titer of anti-DNA antibody. On the other hand, IgG4 anti-U1 RNP antibody significantly correlated with esophageal dilation and muscular involvement. These results may suggest that some IgG subclasses are related to a specific clinical feature or manifestation.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1991 PMID： 1837028 DOI： 10.1007/bf00918797

Source DB: PubMed Journal: J Clin Immunol ISSN： 0271-9142 Impact factor: 8.317

20 in total

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4 in total

Review 1. Anti-Sm autoantibodies in systemic lupus erythematosus mice: a model system for disease-specific autoreactivity.

Authors: R A Eisenberg
Journal: Springer Semin Immunopathol Date: 1992