Literature DB >> 18370225

Taking electroporation-based delivery of DNA vaccination into humans: a generic clinical protocol.

Torunn Elisabeth Tjelle1, Dietmar Rabussay, Christian Ottensmeier, Iacob Mathiesen, Rune Kjeken.   

Abstract

We are presently aware of two early-phase DNA vaccine clinical trials in humans using electroporation-enhanced vaccine delivery. Moreover, two phase I immunogenetherapy studies are in progress and several tolerability studies have been performed on healthy volunteers. We have used knowledge from these studies to compose a template for clinical protocols involving electroporation-mediated gene delivery. In this template the emphasis will be on aspects related to electroporation. In addition, we will discuss general topics concerning electroporation-augmented DNA vaccination in human subjects.

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Year:  2008        PMID： 18370225     DOI： 10.1007/978-1-59745-194-9_39

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  5 in total

1.  Antibodies designed as effective cancer vaccines.

Authors:  R L Metheringham; V A Pudney; B Gunn; M Towey; I Spendlove; L G Durrant
Journal:  MAbs       Date:  2009 Jan-Feb       Impact factor: 5.857

2.  Optimization of electroporation-enhanced intradermal delivery of DNA vaccine using a minimally invasive surface device.

Authors:  Feng Lin; Xuefei Shen; Gleb Kichaev; Janess M Mendoza; Maria Yang; Philip Armendi; Jian Yan; Gary P Kobinger; Alexander Bello; Amir S Khan; Kate E Broderick; Niranjan Y Sardesai
Journal:  Hum Gene Ther Methods       Date:  2012-07-13       Impact factor: 2.396

3.  Immunogenicity and safety of xenogeneic vascular endothelial growth factor receptor-2 DNA vaccination in mice and dogs.

Authors:  Sofie Denies; Laetitia Cicchelero; Ingeborgh Polis; Niek N Sanders
Journal:  Oncotarget       Date:  2016-03-08

4.  Optimized in vivo transfer of small interfering RNA targeting dermal tissue using in vivo surface electroporation.

Authors:  Kate E Broderick; Amy Chan; Feng Lin; Xuefei Shen; Gleb Kichaev; Amir S Khan; Justin Aubin; Tracy S Zimmermann; Niranjan Y Sardesai
Journal:  Mol Ther Nucleic Acids       Date:  2012-02-14       Impact factor: 10.183

5.  Different immunogenicity but similar antitumor efficacy of two DNA vaccines coding for an antigen secreted in different membrane vesicle-associated forms.

Authors:  Christine Sedlik; James Vigneron; Lea Torrieri-Dramard; Fabien Pitoiset; Jordan Denizeau; Caroline Chesneau; Philippe de la Rochere; Olivier Lantz; Clotilde Thery; Bertrand Bellier
Journal:  J Extracell Vesicles       Date:  2014-08-27
  5 in total

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