Literature DB >> 18369929

Methods to investigate the effects of chronic ethanol on adipocytes.

Becky M Sebastian1, Li Kang, Xiaocong Chen, Laura E Nagy.   

Abstract

Chronic ethanol consumption dysregulates glucose and lipid homeostasis, is associated with insulin resistance, and alters serum levels of adipokines including adiponectin and tumor necrosis factor-alpha. However, the mechanisms involved in these chronic ethanol-induced pathologies are not fully understood. Adipose tissue has been implicated as an important contributor to chronic ethanol-induced disease states and, therefore, the effects of chronic ethanol feeding in rats on adipocytes has been investigated. Three major functions of the adipocyte include glucose transport, adipokine secretion, and triglyceride breakdown via lipolysis. Included in this chapter are protocols for studying the effect of chronic ethanol feeding on these adipocyte functions.

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Year:  2008        PMID： 18369929     DOI： 10.1007/978-1-59745-242-7_23

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  6 in total

1.  Identification of a cytochrome P4502E1/Bid/C1q-dependent axis mediating inflammation in adipose tissue after chronic ethanol feeding to mice.

Authors:  Becky M Sebastian; Sanjoy Roychowdhury; Hui Tang; Antoinette D Hillian; Ariel E Feldstein; Gregory L Stahl; Kazue Takahashi; Laura E Nagy
Journal:  J Biol Chem       Date:  2011-08-19       Impact factor: 5.157

2.  Function of phosphoenolpyruvate carboxykinase in mammary gland epithelial cells.

Authors:  Chang-Wen Hsieh; Charles Huang; Ilya Bederman; Jianqi Yang; Michelle Beidelschies; Maria Hatzoglou; Michelle Puchowicz; Colleen M Croniger
Journal:  J Lipid Res       Date:  2011-04-19       Impact factor: 5.922

3.  Ethanol-induced oxidative stress via the CYP2E1 pathway disrupts adiponectin secretion from adipocytes.

Authors:  Hui Tang; Becky M Sebastian; Armend Axhemi; Xiaocong Chen; Antoinette D Hillian; Donald W Jacobsen; Laura E Nagy
Journal:  Alcohol Clin Exp Res       Date:  2011-09-06       Impact factor: 3.455

4.  PPARdelta agonist attenuates alcohol-induced hepatic insulin resistance and improves liver injury and repair.

Authors:  Maoyin Pang; Suzanne M de la Monte; Lisa Longato; Ming Tong; Jiman He; Rajeeve Chaudhry; Kevin Duan; Jiyun Ouh; Jack R Wands
Journal:  J Hepatol       Date:  2009-03-20       Impact factor: 25.083

5.  Reduced milk triglycerides in mice lacking phosphoenolpyruvate carboxykinase in mammary gland adipocytes and white adipose tissue contribute to the development of insulin resistance in pups.

Authors:  Chang-Wen Hsieh; Carrie A Millward; David DeSantis; Sorana Pisano; Jana Machova; Jose C Perales; Colleen M Croniger
Journal:  J Nutr       Date:  2009-10-07       Impact factor: 4.798

6.  Anaphylatoxin Receptors C3aR and C5aR1 Are Important Factors That Influence the Impact of Ethanol on the Adipose Secretome.

Authors:  Rebecca L McCullough; Megan R McMullen; Kyle L Poulsen; Adam Kim; M Edward Medof; Laura E Nagy
Journal:  Front Immunol       Date:  2018-09-20       Impact factor: 7.561
  6 in total

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