Secretory and cytosolic (pro)renin in kidney, heart, and adrenal gland.

Renin is commonly known as a secretory glycoprotein, which is expressed, stored, and secreted in a regulated manner by the kidney. The rat kidney exclusively expresses secretory renin. In this organ, renin regulates glomerular filtration rate, vascular resistance, and sodium reabsorbtion. In the adult rat heart, secretory preprorenin is not expressed. Instead, an alternative renin transcript is expressed that encodes for a previously unrecognized cytosolic renin. The expression of cytosolic but not of secretory renin increases markedly after myocardial infarction, indicating a role specifically for cytosolic renin in postischemic repair processes. In the adrenal gland, secretory renin is expressed and provides the basis for an intra-adrenal angiotensin (ANG) II amplification system. This amplification system reduces the demand for circulating ANGII to stimulate aldosterone production and thus minimizes any detrimental effects of circulating ANGII in other tissues. The adrenal gland additionally expresses cytosolic renin, which is targeted to mitochondria. Adrenal cytosolic renin increases aldosterone production plasma renin independently.