Literature DB >> 18368168

A mechanistic study on the oxidation of hydrazides: application to the tuberculosis drug isoniazid.

Ruth I J Amos1, Brendon S Gourlay, Carl H Schiesser, Jason A Smith, Brian F Yates.   

Abstract

Herein we report radical trapping experiments that support the formation of an acyl radical as the active species from the oxidation of isoniazid; these data provide insight into the mechanism of hydrazide oxidation.

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Year:  2008        PMID： 18368168     DOI： 10.1039/b719570b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

1.  Isoniazid metal complex reactivity and insights for a novel anti-tuberculosis drug design.

Authors:  Eduardo Henrique Silva Sousa; Luiz Augusto Basso; Diógenes S Santos; Izaura Cirino Nogueira Diógenes; Elisane Longhinotti; Luiz Gonzaga de França Lopes; Icaro de Sousa Moreira
Journal:  J Biol Inorg Chem       Date:  2011-09-28       Impact factor: 3.358

2.  Isonicotinic acid hydrazide conversion to Isonicotinyl-NAD by catalase-peroxidases.

Authors:  Ben Wiseman; Xavi Carpena; Miguel Feliz; Lynda J Donald; Miquel Pons; Ignacio Fita; Peter C Loewen
Journal:  J Biol Chem       Date:  2010-06-15       Impact factor: 5.157

3.  Access channel residues Ser315 and Asp137 in Mycobacterium tuberculosis catalase-peroxidase (KatG) control peroxidatic activation of the pro-drug isoniazid.

Authors:  Xiangbo Zhao; Hans-Petter Hersleth; Janan Zhu; K Kristoffer Andersson; Richard S Magliozzo
Journal:  Chem Commun (Camb)       Date:  2013-12-25       Impact factor: 6.222

4.  Biologically important hydrazide-containing fused azaisocytosines as antioxidant agents.

Authors:  Małgorzata Sztanke; Krzysztof Sztanke
Journal:  Redox Rep       Date:  2017-08-16       Impact factor: 4.412
  4 in total

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