Literature DB >> 1836750

Appearance of the T-cell marker CD8 on B chronic lymphatic leukemia cells in long-term cultures.

R Farkas1, S Ben-Efraim, Y Manor, I Zan-Bar, A Klajman.   

Abstract

Long-term cultures of highly purified B chronic lymphatic leukemia cells (B-CLL), were established. The B-CLL lymphocytes acquired the CD8 T cell marker in long-term cultures while still retaining their surface immunoglobulins. In confirmation of previous results, the cultured B-CLL lymphocytes released factor(s) into the culture medium that suppressed the allogeneic mixed-lymphocyte reaction. No correlation was found between the appearance of the CD8 T cell surface marker and onset of suppressor activity.

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Year:  1991        PMID： 1836750     DOI： 10.1007/bf01742310

Source DB:  PubMed          Journal:  Cancer Immunol Immunother        ISSN： 0340-7004            Impact factor:   6.968


  25 in total

1.  Clonal analysis of human tumor infiltrating lymphocytes reactive with autologous tumor cells: different target cell specificities of NK-like and cytotoxic T-cell clones.

Authors:  H Rabinowich; Z Steiner; A Klajman
Journal:  Cell Immunol       Date:  1987-02       Impact factor: 4.868

2.  Preparation of antisera with specificity for human T lymphocytes.

Authors:  H Zola
Journal:  Transplantation       Date:  1977-03       Impact factor: 4.939

3.  Isolation and characterization of human B cell alloantigens.

Authors:  R J Billing; M Safani; P Peterson
Journal:  J Immunol       Date:  1976-11       Impact factor: 5.422

4.  Dual B and T markers in acute and chronic lymphocytic leukemia.

Authors:  K A Foon; R J Billing; P I Terasaki
Journal:  Blood       Date:  1980-01       Impact factor: 22.113

5.  Some chronic lymphocytic leukemia cells bearing surface immunoglobulins share determinants with T cells.

Authors:  L Boumsell; A Bernard; V Lepage; L Degos; J Lemerle; J Dausset
Journal:  Eur J Immunol       Date:  1978-12       Impact factor: 5.532

6.  Immunologic classification of lymphocytic leukemias based on monoclonal antibody-defined cell surface antigens.

Authors:  R W Schroff; K A Foon; R J Billing; J L Fahey
Journal:  Blood       Date:  1982-02       Impact factor: 22.113

7.  Long-term culture and cloning of nontransformed human B lymphocytes.

Authors:  B Sredni; D G Sieckmann; S Kumagai; S House; I Green; W E Paul
Journal:  J Exp Med       Date:  1981-11-01       Impact factor: 14.307

8.  Immunoglobulins on the surface of lymphocytes. II. The bone marrow as the main source of lymphocytes with detectable surface-bound immunoglobulin.

Authors:  E R Unanue; H M Grey; E Rabellino; P Campbell; J Schmidtke
Journal:  J Exp Med       Date:  1971-06-01       Impact factor: 14.307

9.  A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. I. Separation and characterization.

Authors:  C Bianco; R Patrick; V Nussenzweig
Journal:  J Exp Med       Date:  1970-10-01       Impact factor: 14.307

10.  Identification of a p69,71 complex expressed on human T cells sharing determinants with B-type chronic lymphatic leukemic cells.

Authors:  C Y Wang; R A Good; P Ammirati; G Dymbort; R L Evans
Journal:  J Exp Med       Date:  1980-06-01       Impact factor: 14.307
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  2 in total

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Authors:  Ramothea L Webster; R Paul Johnson
Journal:  Immunology       Date:  2005-06       Impact factor: 7.397

2.  Interleukin-6 and interleukin-6 receptor secretion by chronic lymphatic leukaemia and normal B lymphocytes: effect of PMA and PWM.

Authors:  I Drucker; A Klajman; M Revel; Y Manor; S Ben-Efraim; D Novick
Journal:  Mediators Inflamm       Date:  1997       Impact factor: 4.711
  2 in total

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