| Literature DB >> 18367395 |
Annie Mayence1, Aurélie Pietka, Margaret S Collins, Melanie T Cushion, Babu L Tekwani, Tien L Huang, Jean Jacques Vanden Eynde.
Abstract
A small library of 2,2'-[(alpha,omega-alkanediylbis(oxyphenylene)]bis-1H-benzimidazoles has been prepared and screened in vitro against Pneumocystis carinii, Trypanosoma brucei rhodesiense, and Leishmania donovani. Among the six tested compounds two derivatives emerged as promising hits characterized by IC(50) values lower than that determined for pentamidine against L. donovani.Entities:
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Year: 2008 PMID： 18367395 DOI： 10.1016/j.bmcl.2008.03.020
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823