Literature DB >> 18367258

Evaluation of a neurodevelopmental model of schizophrenia--early postnatal PCP treatment in attentional set-shifting.

Brian Villumsen Broberg1, Rebecca Dias, Birte Yding Glenthøj, Christina Kurre Olsen.   

Abstract

Phencyclidine (PCP) was administered to male and female Lister hooded rats on postnatal days (PND) 7, 9 and 11. All PCP animals tested in adulthood (PND 53-93) showed deficits in cognitive flexibility, specifically in their ability to shift attentional set, compared to controls. This novel finding is reminiscent of the impairment observed in schizophrenia patients, and supports the validity of the early postnatal PCP regimen as a disease-like model.

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Year:  2008        PMID： 18367258     DOI： 10.1016/j.bbr.2008.02.020

Source DB:  PubMed          Journal:  Behav Brain Res        ISSN： 0166-4328            Impact factor:   3.332


  25 in total

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Authors:  Christina Wilson; Alvin V Terry
Journal:  Clin Schizophr Relat Psychoses       Date:  2010-07

Review 2.  CNTRICS final task selection: executive control.

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3.  Deletion of the Mitochondrial Matrix Protein CyclophilinD Prevents Parvalbumin Interneuron Dysfunctionand Cognitive Deficits in a Mouse Model of NMDA Hypofunction.

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Review 4.  Glutamatergic regulation of cognition and functional brain connectivity: insights from pharmacological, genetic and translational schizophrenia research.

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Review 5.  Disruption of performance in the five-choice serial reaction time task induced by administration of N-methyl-D-aspartate receptor antagonists: relevance to cognitive dysfunction in schizophrenia.

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6.  Different effects of isolation-rearing and neonatal MK-801 treatment on attentional modulations of prepulse inhibition of startle in rats.

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7.  Activation of dopamine D1 receptors blocks phencyclidine-induced neurotoxicity by enhancing N-methyl-D-aspartate receptor-mediated synaptic strength.

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8.  Ethanol and phencyclidine interact with respect to nucleus accumbens dopamine release: differential effects of administration order and pretreatment protocol.

Authors:  Chris Pickering; Pei Pei Chau; Bo Söderpalm; Mia Ericson
Journal:  Front Behav Neurosci       Date:  2010-06-10       Impact factor: 3.558

9.  Predictably irrational: assaying cognitive inflexibility in mouse models of schizophrenia.

Authors:  Jonathan L Brigman; Carolyn Graybeal; Andrew Holmes
Journal:  Front Neurosci       Date:  2010-05-15       Impact factor: 4.677

10.  In vitro and in vivo characterisation of Lu AF64280, a novel, brain penetrant phosphodiesterase (PDE) 2A inhibitor: potential relevance to cognitive deficits in schizophrenia.

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Journal:  Psychopharmacology (Berl)       Date:  2014-03-01       Impact factor: 4.530
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