OBJECTIVE: To determine a successful method of selecting patients for natural cycle IVF combined with in vitro maturation (IVM) of immature oocytes and to determine treatment efficacy. DESIGN: Retrospective analysis of IVF treatments. SETTING: Hospital IVF clinic. PATIENT(S): Women with infertility according to ovarian reserve and endocrine profile were selected for different treatments. INTERVENTIONS(S): According to screening criteria, infertile women were divided into three treatments: [1] natural cycle IVF combined with IVM (IVF/M), [2] IVM alone, and [3] controlled ovarian hyperstimulation (COH) with gonadotropin. MAIN OUTCOME MEASURE(S): The distribution of completed IVF-ET cycles in each treatment; clinical pregnancy and implantation rates in each treatment. RESULT(S): A total of 417 cycles were started, and 410 cycles (98.3%) were completed. Of 410 cycles, 151 (36.8%) were treated by natural cycle IVF/M, 63 (15.4%) underwent IVM alone, and 196 (47.8%) underwent COH. With increasing age fewer cycles can be treated by natural cycle IVF/M or IVM. Clinical pregnancy rates were 40.4% (61 of 151) for natural cycle IVF/M, 41.3% (26 of 63) for IVM alone, and 37.8% (74 of 196) for COH. There were no differences in implantation rate in the three groups (17.8% [82 of 462], 16.7% [35 of 210], and 20.1% [103 of 513]). CONCLUSION(S): Natural cycle IVF/M together with IVM-alone treatment can offer more than 50% of infertile women with an acceptable pregnancy and implantations rates.
OBJECTIVE: To determine a successful method of selecting patients for natural cycle IVF combined with in vitro maturation (IVM) of immature oocytes and to determine treatment efficacy. DESIGN: Retrospective analysis of IVF treatments. SETTING: Hospital IVF clinic. PATIENT(S): Women with infertility according to ovarian reserve and endocrine profile were selected for different treatments. INTERVENTIONS(S): According to screening criteria, infertilewomen were divided into three treatments: [1] natural cycle IVF combined with IVM (IVF/M), [2] IVM alone, and [3] controlled ovarian hyperstimulation (COH) with gonadotropin. MAIN OUTCOME MEASURE(S): The distribution of completed IVF-ET cycles in each treatment; clinical pregnancy and implantation rates in each treatment. RESULT(S): A total of 417 cycles were started, and 410 cycles (98.3%) were completed. Of 410 cycles, 151 (36.8%) were treated by natural cycle IVF/M, 63 (15.4%) underwent IVM alone, and 196 (47.8%) underwent COH. With increasing age fewer cycles can be treated by natural cycle IVF/M or IVM. Clinical pregnancy rates were 40.4% (61 of 151) for natural cycle IVF/M, 41.3% (26 of 63) for IVM alone, and 37.8% (74 of 196) for COH. There were no differences in implantation rate in the three groups (17.8% [82 of 462], 16.7% [35 of 210], and 20.1% [103 of 513]). CONCLUSION(S): Natural cycle IVF/M together with IVM-alone treatment can offer more than 50% of infertilewomen with an acceptable pregnancy and implantations rates.
Authors: Kyung Sil Lim; Soo Jin Chae; Chang Woo Choo; Yeon Hee Ku; Hye Jun Lee; Chang Young Hur; Jin Ho Lim; Won Don Lee Journal: Clin Exp Reprod Med Date: 2013-12-31