| Literature DB >> 18365695 |
Young Taek Sohn1, Sang Hee Kim.
Abstract
Four crystal modifications of acyclovir were isolated by recrystallization and characterized by powder X-ray diffractometry, differential scanning calorimetry, and thermogravimetric analysis. It was confirmed that Form 3 is a hydrate and Form 4 is an acetic acid solvate. The dissolution patterns of three crystal forms of acyclovir were studied in water at 37 +/- 0.5 degrees C, 90 rpm for 120 minutes. The amount dissolved at 120 minutes was highest for Form 1, followed by Form 2 and Form 3. After storage of 25 hours at 0% RH (silica gel, 20 degrees C) Form 3 was transformed to Form 2.Entities:
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Year: 2008 PMID： 18365695 DOI： 10.1007/s12272-001-1146-x
Source DB: PubMed Journal: Arch Pharm Res ISSN： 0253-6269 Impact factor: 4.946