Synthesis, spectroscopic and physicochemical characterization and biological activity of Co(II) and Ni(II) coordination compounds with 4-aminoantipyrine thiosemicarbazone.

We describe the synthesis and characterization of cobalt(II) and nickel(II) coordination compounds of 4[N-(furan-2'-aldimine)amino]antipyrine thiosemicarbazone (FFAAPTS) and 4[N-(4'-nitrobenzalidene) amino]antipyrine thiosemicarbazone (4'-NO(2)BAAPTS). All the isolated compounds have the general composition MX(2)(L)(H(2)O) (M = Co(2+) or Ni(2+); X = Cl, Br, NO(3), NCS or CH(3)COO; L = FFAAPTS or 4'-NO(2)BAAPTS) and M(ClO(4))(2)(L)(2) (M = Co(2+) or Ni(2+); L = FFAAPTS or 4'-NO(2)BAAPTS). Infrared spectral studies indicate that both the thiosemicarbazones coordinate in their neutral form and they act as {N,N,S} tridentate chelating ligands. Room temperature magnetic measurements and electronic spectral studies suggest the distorted octahedral geometries of the prepared complexes. Thermogravimetric studies are also reported and the possible structures of the complexes are proposed. Antibacterial and antifungal properties of these metal-coordination compounds have also been studied.