OBJECTIVE: i) to describe the neuropsychiatric profile of elderly subjects with dementia by comparing vascular (VaD) and degenerative dementias, i.e. dementia with Lewy bodies (DLB) and Alzheimer's disease (AD); ii) to assess whether the severity and type of dementia are associated with clinically relevant neuropsychiatric symptoms (CR-NPS). METHOD: One hundred and thirty-one out-patients with VaD, 100 with DLB and 690 with AD were studied. NPS were evaluated by the neuropsychiatric inventory (NPI). RESULTS: Vascular dementia had lower total and domain-specific NPI scores and a lower frequency of CR-NPS than AD and DLB, for which frequency of CR-NPS increased significantly with disease severity, particularly in AD. Logistic regression analysis showed that a higher CDR score and a diagnosis of degenerative dementia were independently associated with CR-NPS. CONCLUSION: Vascular dementia is associated less with CR-NPS than AD and DLB. Frequency of CR-NPS increases with disease severity in AD and, to a lesser extent, in DLB.
OBJECTIVE: i) to describe the neuropsychiatric profile of elderly subjects with dementia by comparing vascular (VaD) and degenerative dementias, i.e. dementia with Lewy bodies (DLB) and Alzheimer's disease (AD); ii) to assess whether the severity and type of dementia are associated with clinically relevant neuropsychiatric symptoms (CR-NPS). METHOD: One hundred and thirty-one out-patients with VaD, 100 with DLB and 690 with AD were studied. NPS were evaluated by the neuropsychiatric inventory (NPI). RESULTS:Vascular dementia had lower total and domain-specific NPI scores and a lower frequency of CR-NPS than AD and DLB, for which frequency of CR-NPS increased significantly with disease severity, particularly in AD. Logistic regression analysis showed that a higher CDR score and a diagnosis of degenerative dementia were independently associated with CR-NPS. CONCLUSION:Vascular dementia is associated less with CR-NPS than AD and DLB. Frequency of CR-NPS increases with disease severity in AD and, to a lesser extent, in DLB.
Authors: Brendan J Guercio; Nancy J Donovan; Catherine E Munro; Sarah L Aghjayan; Sarah E Wigman; Joseph J Locascio; Rebecca E Amariglio; Dorene M Rentz; Keith A Johnson; Reisa A Sperling; Gad A Marshall Journal: J Alzheimers Dis Date: 2015 Impact factor: 4.472
Authors: Jennifer R Gatchel; Nancy J Donovan; Joseph J Locascio; J Alex Becker; Dorene M Rentz; Reisa A Sperling; Keith A Johnson; Gad A Marshall Journal: Am J Geriatr Psychiatry Date: 2017-01-04 Impact factor: 4.105
Authors: Hogne Soennesyn; Ketil Oppedal; Ole Jacob Greve; Friederike Fritze; Bjørn H Auestad; Sabine P Nore; Mona K Beyer; Dag Aarsland Journal: Dement Geriatr Cogn Dis Extra Date: 2012-03-31