Literature DB >> 18363588

Integrating research into routine service delivery in an antiretroviral treatment programme: lessons learnt from a cluster randomized trial comparing strategies of HIV care in Jinja, Uganda.

Shabbar Jaffar1, Barbara Amuron, Josephine Birungi, Geoffrey Namara, Christine Nabiryo, Alex Coutinho, Heiner Grosskurth.   

Abstract

Trials integrated into normal health service delivery are designed to evaluate the effectiveness of interventions under real-life conditions. However, integrating research into service delivery creates many operational challenges and raises ethical dilemmas. Here we discuss the operational and ethical issues arising from such trials using the example of a cluster randomized trial evaluating two strategies of ART delivery in Jinja, south-east Uganda.

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Year:  2008        PMID： 18363588     DOI： 10.1111/j.1365-3156.2008.02068.x

Source DB:  PubMed          Journal:  Trop Med Int Health        ISSN： 1360-2276            Impact factor:   2.622


  13 in total

1.  Supporting southern-led research: implications for North-South research partnerships.

Authors:  Katherine A Muldoon; Josephine Birungi; Nicole S Berry; Moses H Ngolobe; Robert Mwesigwa; Kate Shannon; David M Moore
Journal:  Can J Public Health       Date:  2012 Mar-Apr

Review 2.  Early phase clinical trials with human immunodeficiency virus-1 and malaria vectored vaccines in The Gambia: frontline challenges in study design and implementation.

Authors:  Muhammed O Afolabi; Jane U Adetifa; Egeruan B Imoukhuede; Nicola K Viebig; Beate Kampmann; Kalifa Bojang
Journal:  Am J Trop Med Hyg       Date:  2014-03-10       Impact factor: 2.345

3.  ABC for people with HIV: responses to sexual behaviour recommendations among people receiving antiretroviral therapy in Jinja, Uganda.

Authors:  Caroline Allen; Martin Mbonye; Janet Seeley; Josephine Birungi; Brent Wolff; Alex Coutinho; Shabbar Jaffar
Journal:  Cult Health Sex       Date:  2011-05

4.  Mortality in an antiretroviral therapy programme in Jinja, south-east Uganda: a prospective cohort study.

Authors:  Barbara Amuron; Jonathan Levin; Josephine Birunghi; Geoffrey Namara; Alex Coutinho; Heiner Grosskurth; Shabbar Jaffar
Journal:  AIDS Res Ther       Date:  2011-10-22       Impact factor: 2.250

5.  Health providers' perceptions of clinical trials: lessons from Ghana, Kenya and Burkina Faso.

Authors:  Vibian Angwenyi; Kwaku-Poku Asante; Abdoulaye Traoré; Lawrence Gyabaa Febir; Charlotte Tawiah; Anthony Kwarteng; Alphonse Ouédraogo; Sodiomon Bienvenue Sirima; Seth Owusu-Agyei; Egeruan Babatunde Imoukhuede; Jayne Webster; Daniel Chandramohan; Sassy Molyneux; Caroline Jones
Journal:  PLoS One       Date:  2015-05-01       Impact factor: 3.240

6.  Mortality and loss-to-follow-up during the pre-treatment period in an antiretroviral therapy programme under normal health service conditions in Uganda.

Authors:  Barbara Amuron; Geoffrey Namara; Josephine Birungi; Christine Nabiryo; Jonathan Levin; Heiner Grosskurth; Alex Coutinho; Shabbar Jaffar
Journal:  BMC Public Health       Date:  2009-08-11       Impact factor: 3.295

7.  Rates of virological failure in patients treated in a home-based versus a facility-based HIV-care model in Jinja, southeast Uganda: a cluster-randomised equivalence trial.

Authors:  Shabbar Jaffar; Barbara Amuron; Susan Foster; Josephine Birungi; Jonathan Levin; Geoffrey Namara; Christine Nabiryo; Nicaise Ndembi; Rosette Kyomuhangi; Alex Opio; Rebecca Bunnell; Jordan W Tappero; Jonathan Mermin; Alex Coutinho; Heiner Grosskurth
Journal:  Lancet       Date:  2009-11-24       Impact factor: 79.321

8.  SUPPORT tools for evidence-informed policymaking in health 18: Planning monitoring and evaluation of policies.

Authors:  Atle Fretheim; Andrew D Oxman; John N Lavis; Simon Lewin
Journal:  Health Res Policy Syst       Date:  2009-12-16

9.  Community health workers for ART in sub-Saharan Africa: learning from experience--capitalizing on new opportunities.

Authors:  Katharina Hermann; Wim Van Damme; George W Pariyo; Erik Schouten; Yibeltal Assefa; Anna Cirera; William Massavon
Journal:  Hum Resour Health       Date:  2009-04-09

10.  Use of WHO clinical stage for assessing patient eligibility to antiretroviral therapy in a routine health service setting in Jinja, Uganda.

Authors:  Shabbar Jaffar; Josephine Birungi; Heiner Grosskurth; Barbara Amuron; Geoffrey Namara; Christine Nabiryo; Alex Coutinho
Journal:  AIDS Res Ther       Date:  2008-02-28       Impact factor: 2.250
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