| Literature DB >> 18363363 |
Mette Louise H Mantel1, Lina S Søbjerg, Tri H V Huynh, Jean-Philippe Ebran, Anders T Lindhardt, Niels C Nielsen, Troels Skrydstrup.
Abstract
The styryl benzene derivative (E, E)-1-fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (FSB), well-known for its binding to beta-amyloid peptide fibrils, was synthesized in an efficient manner exploiting two sequential palladium(0)-catalyzed coupling reactions in a 34% overall yield. This is a substantial improvement to the previously reported synthesis of FSB in 1.1%.Entities:
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Year: 2008 PMID： 18363363 DOI： 10.1021/jo7026189
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354