OBJECTIVE: Residence at high altitude has been associated with elevation in systemic blood pressure (BP), but few studies have been done on the time course and the effects of a median altitude. Moreover, there exist population differences in the reactions given to altitude and the mechanism is unknown. This study was therefore designed to determine the effects of a median altitude on resting BP and heart rate (HR) in a group of 15 healthy, young, Turkish male subjects. METHODS: After basic measurements were carried out in Bursa (155 m), subjects were transported to a mountain hotel (altitude 1,860 m), where the measurements were repeated once every 15 days during a 10-month period. RESULTS: Mean BP and diastolic BP increased on Day 4 and then remained above first values throughout the study. Compared with control measurements, high altitude increased systolic blood pressure (SBP) in all subjects, but in Month 4 and Month 6, SBP returned to control values, and remained elevated thereafter. HR continued to decrease in parallel with time and significant decrease occurred after Month 5. INTERPRETATION: Our findings imply that moderate-altitude living results in a significantly greater BP and lower HR over equivalent low-altitude measurements and we conclude that chronic exposure to hypobaric hypoxia at a median altitude causes increased parasympathetic and sympathetic tone in healthy, young, Turkish males.
OBJECTIVE: Residence at high altitude has been associated with elevation in systemic blood pressure (BP), but few studies have been done on the time course and the effects of a median altitude. Moreover, there exist population differences in the reactions given to altitude and the mechanism is unknown. This study was therefore designed to determine the effects of a median altitude on resting BP and heart rate (HR) in a group of 15 healthy, young, Turkish male subjects. METHODS: After basic measurements were carried out in Bursa (155 m), subjects were transported to a mountain hotel (altitude 1,860 m), where the measurements were repeated once every 15 days during a 10-month period. RESULTS: Mean BP and diastolic BP increased on Day 4 and then remained above first values throughout the study. Compared with control measurements, high altitude increased systolic blood pressure (SBP) in all subjects, but in Month 4 and Month 6, SBP returned to control values, and remained elevated thereafter. HR continued to decrease in parallel with time and significant decrease occurred after Month 5. INTERPRETATION: Our findings imply that moderate-altitude living results in a significantly greater BP and lower HR over equivalent low-altitude measurements and we conclude that chronic exposure to hypobaric hypoxia at a median altitude causes increased parasympathetic and sympathetic tone in healthy, young, Turkish males.
Authors: V E Claydon; L J Norcliffe; J P Moore; M Rivera-Ch; F Leon-Velarde; O Appenzeller; R Hainsworth Journal: Exp Physiol Date: 2004-06-07 Impact factor: 2.969
Authors: L Bernardi; C Passino; G Spadacini; A Calciati; R Robergs; R Greene; E Martignoni; I Anand; O Appenzeller Journal: Clin Sci (Lond) Date: 1998-11 Impact factor: 6.124
Authors: C Passino; L Bernardi; G Spadacini; A Calciati; R Robergs; I Anand; R Greene; E Martignoni; O Appenzeller Journal: Clin Sci (Lond) Date: 1996 Impact factor: 6.124
Authors: Yang Liu; Ji-Hang Zhang; Xu-Bin Gao; Xiao-Jing Wu; Jie Yu; Jian-Fei Chen; Shi-Zhu Bian; Xiao-Han Ding; Lan Huang Journal: Mil Med Res Date: 2014-08-26
Authors: Jonas Früh; Andre Fuchs; Tafese Beyene Tufa; Loraine Früh; Zewdu Hurissa; Hans Martin Orth; Johannes Georg Bode; Kirsten Alexandra Eberhardt; Dieter Häussinger; Torsten Feldt Journal: PLoS One Date: 2021-02-04 Impact factor: 3.240