| Literature DB >> 18363031 |
Hae-Yun Jung1, Young Mi Whang1, Jae Sook Sung1, Hyoung Doo Shin1,2, Byung Lae Park1,2, Jun Suk Kim3, Sang Won Shin3, Hee Yun Seo3, Jae Hong Seo3, Yeul Hong Kim4.
Abstract
The tumor suppressor gene, TP53, is located on chromosome 17p13.1 and is critical for DNA repair, cell-cycle control, and apoptosis. TP53 also plays a crucial function in the tumorigenesis of lung cancer. Inactivation of TP53 via genetic alterations such as missense mutations is often associated with lung cancer. In this study, potential association of TP53 polymorphisms with the risk of lung cancer was examined in a Korean population. A total of 299 Korean lung cancer patients and 296 control subjects were recruited into this study. Direct DNA sequencing and TaqMan analysis were employed, and logistic regression analyses were conducted to characterize the association between TP53 polymorphisms and lung cancer risk. Through direct sequencing in 24 Korean individuals, 13 sequence variants were identified, and five of these polymorphisms were selected for a larger-scale genotyping (n = 595). Statistical analyses revealed that polymorphisms and haplotypes in the TP53 gene, including Arg72Pro, were not significantly associated with lung cancer in a Korean population.Entities:
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Year: 2008 PMID： 18363031 DOI： 10.1007/s10038-008-0278-y
Source DB: PubMed Journal: J Hum Genet ISSN： 1434-5161 Impact factor: 3.172