Literature DB >> 18362955

Bifunctional ligands based on the DOTA-monoamide cage.

Alessandro Barge1, Lorenzo Tei, Dharita Upadhyaya, Franco Fedeli, Lorena Beltrami, Rachele Stefanìa, Silvio Aime, Giancarlo Cravotto.   

Abstract

Efficient routes to DOTA-monoamide ligands bearing amino, hydroxyl, aldehyde and maleimido groups are described. These functional groups, which can be spaced at will from the coordination cage, will readily react with suitable groups of targeting moieties. Bioconjugates obtained in this way can be used for diagnostic imaging and therapeutic applications.

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Year:  2008        PMID： 18362955     DOI： 10.1039/b715844k

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  6 in total

1.  On the Synthesis of 1,4,7-Tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane.

Authors:  Bhumasamudram Jagadish; Gayle L Brickert-Albrecht; Gary S Nichol; Eugene A Mash; Natarajan Raghunand
Journal:  Tetrahedron Lett       Date:  2011-04-27       Impact factor: 2.415

2.  Strategies for the preparation of bifunctional gadolinium(III) chelators.

Authors:  Luca Frullano; Peter Caravan
Journal:  Curr Org Synth       Date:  2011-08-01       Impact factor: 1.975

3.  SIB-DOTA: a trifunctional prosthetic group potentially amenable for multi-modal labeling that enhances tumor uptake of internalizing monoclonal antibodies.

Authors:  G Vaidyanathan; B J White; D J Affleck; X G Zhao; P C Welsh; D McDougald; J Choi; M R Zalutsky
Journal:  Bioorg Med Chem       Date:  2012-10-29       Impact factor: 3.641

4.  IMPROVED SYNTHESIS OF 10-(2-ALKYLAMINO-2-OXOETHYL)-1,4,7,10-TETRAAZACYCLODODECANE-1,4,7-TRIACETIC ACID DERIVATIVES BEARING ACID-SENSITIVE LINKERS.

Authors:  Bhumasamudram Jagadish; Tarik J Ozumerzifon; Sue A Roberts; Gabriel B Hall; Eugene A Mash; Natarajan Raghunand
Journal:  Synth Commun       Date:  2014       Impact factor: 2.007

5.  Synthesis of a DOTA-C-glyco bifunctional chelating agent and preliminary in vitro and in vivo study of [68Ga]Ga-DOTA-C-glyco-RGD.

Authors:  Floriane Mangin; Charlotte Collet; Valérie Jouan-Hureaux; Fatiha Maskali; Emilie Roeder; Julien Pierson; Katalin Selmeczi; Pierre-Yves Marie; Cédric Boura; Nadia Pellegrini-Moïse; Sandrine Lamandé-Langle
Journal:  RSC Adv       Date:  2021-02-17       Impact factor: 3.361

6.  A convenient and efficient total solid-phase synthesis of DOTA-functionalized tumor-targeting peptides for PET imaging of cancer.

Authors:  Subhani M Okarvi; Ibrahim AlJammaz
Journal:  EJNMMI Res       Date:  2019-09-10       Impact factor: 3.138
  6 in total

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