BACKGROUND: Quantitative assessment of ventricular volumes and mass in pediatric patients with single-ventricle physiology would aid clinical management, but it is difficult to obtain with 2-dimensional echocardiography. The purpose of the present study was to compare matrix-array 3-dimensional echocardiography (3DE) measurements of single-ventricle volumes, mass, and ejection fraction with those measured by cardiac magnetic resonance (CMR) in young patients. METHODS AND RESULTS: Twenty-nine patients (median age, 7 months) with a functional single ventricle undergoing CMR under general anesthesia were prospectively enrolled. The 3DE images were acquired at the conclusion of the CMR. Twenty-seven of 29 3DE data sets (93%) were optimal for 3DE assessment. Two blinded and independent observers performed 3DE measurements of volume, mass, and ejection fraction. The 3DE end-diastolic volume correlated well (r=0.96) but was smaller than CMR by 9% (P<0.01), and 3DE ejection fraction was smaller than CMR by 11% (P<0.01). There was no significant difference in measurements of end-systolic volume and mass. The 3DE interobserver differences for mass and volumes were not significant except for ejection fraction (8% difference; P<0.05). Intraobserver differences were not significant. CONCLUSIONS: In young pediatric patients with a functional single ventricle, matrix-array 3DE measurements of mass and volumes compare well with those obtained by CMR. 3DE will provide an important modality for the serial analysis of ventricular size and performance in young patients with functional single ventricles.
BACKGROUND: Quantitative assessment of ventricular volumes and mass in pediatric patients with single-ventricle physiology would aid clinical management, but it is difficult to obtain with 2-dimensional echocardiography. The purpose of the present study was to compare matrix-array 3-dimensional echocardiography (3DE) measurements of single-ventricle volumes, mass, and ejection fraction with those measured by cardiac magnetic resonance (CMR) in young patients. METHODS AND RESULTS: Twenty-nine patients (median age, 7 months) with a functional single ventricle undergoing CMR under general anesthesia were prospectively enrolled. The 3DE images were acquired at the conclusion of the CMR. Twenty-seven of 29 3DE data sets (93%) were optimal for 3DE assessment. Two blinded and independent observers performed 3DE measurements of volume, mass, and ejection fraction. The 3DE end-diastolic volume correlated well (r=0.96) but was smaller than CMR by 9% (P<0.01), and 3DE ejection fraction was smaller than CMR by 11% (P<0.01). There was no significant difference in measurements of end-systolic volume and mass. The 3DE interobserver differences for mass and volumes were not significant except for ejection fraction (8% difference; P<0.05). Intraobserver differences were not significant. CONCLUSIONS: In young pediatric patients with a functional single ventricle, matrix-array 3DE measurements of mass and volumes compare well with those obtained by CMR. 3DE will provide an important modality for the serial analysis of ventricular size and performance in young patients with functional single ventricles.
Authors: Gerald R Marx; Girish Shirali; Jami C Levine; Lin T Guey; James F Cnota; Jeanne M Baffa; William L Border; Steve Colan; Gregory Ensing; Mark K Friedberg; David J Goldberg; Salim F Idriss; J Blaine John; Wyman W Lai; Minmin Lu; Shaji C Menon; Richard G Ohye; David Saudek; Pierre C Wong; Gail D Pearson Journal: Circ Cardiovasc Imaging Date: 2013-10-04 Impact factor: 7.792
Authors: Francesco Secchi; Elda Chiara Resta; Giovanni Di Leo; Marcello Petrini; Carmelo Messina; Mario Carminati; Francesco Sardanelli Journal: Int J Cardiovasc Imaging Date: 2014-05-07 Impact factor: 2.357
Authors: Renee Margossian; Marcy L Schwartz; Ashwin Prakash; Lisa Wruck; Steven D Colan; Andrew M Atz; Timothy J Bradley; Mark A Fogel; Lynne M Hurwitz; Edward Marcus; Andrew J Powell; Beth F Printz; Michael D Puchalski; Jack Rychik; Girish Shirali; Richard Williams; Shi-Joon Yoo; Tal Geva Journal: Am J Cardiol Date: 2009-06-06 Impact factor: 2.778
Authors: Katharina Linden; Dennis Ladage; Oliver Dewald; Eva Gatzweiler; Andrea Pieper; Matthias Seehase; Georg Daniel Duerr; Johannes Breuer; Ulrike Herberg Journal: J Clin Monit Comput Date: 2016-02-17 Impact factor: 2.502