Literature DB >> 18362068

N-D-aldopentofuranosyl-N'-[p-(isoamyloxy)phenyl]-thiourea derivatives: potential anti-TB therapeutic agents.

Avraham Liav1, Shiva K Angala, Patrick J Brennan, Mary Jackson.   

Abstract

Thiocarlide (THC; N,N'-bis[p-(isoamyloxy)phenyl]-thiourea; also known as isoxyl) has been used in the past as anti-tuberculosis agent. In an effort to improve the therapeutic value of THC several N-pentofuranosyl-N'-[p-(isoamyloxy)phenyl]-thiourea derivatives were synthesized by coupling of an aniline derivative and pentofuranosyl isothiocyanates. The MIC values of the new products against M.tb indicate that this new approach to the synthesis of potential anti-TB therapeutic agents was successful.

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Year:  2008        PMID： 18362068     DOI： 10.1016/j.bmcl.2008.03.033

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

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Journal:  Tuberculosis (Edinb)       Date:  2009-09-15       Impact factor: 3.131

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