Literature DB >> 18361795

Generation of C57BL/6 knockout mice using C3H x BALB/c blastocysts.

Gabriela Pacholczyk1, Rupali Suhag, Magdalena Mazurek, Suzanne M Dederscheck, Pandelakis A Koni.   

Abstract

The International Mouse Knockout Consortium aims to generate a knockout mouse for every single gene on a C57BL/6 background. Our ability to generate such mice is hampered by the poor economics of producing blastocysts to achieve germline transmission of C57BL/6 embryonic stem (ES) cells. We demonstrate superior utility of (C3H x BALB/c)F1 blastocysts compared with BALB/c blastocysts, with blastocyst numbers and germline transmission from subsequent chimeras at a rate 2- to 3-fold higher than that produced with BALB/c blastocysts.

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Year:  2008        PMID： 18361795     DOI： 10.2144/000112706

Source DB:  PubMed          Journal:  Biotechniques        ISSN： 0736-6205            Impact factor:   1.993


  8 in total

1.  Comparison of BALB/c and B6-albino mouse strain blastocysts as hosts for the injection of C57BL6/N-derived C2 embryonic stem cells.

Authors:  Tuija M Alcantar; Rhonda Wiler; Xin Y Rairdan
Journal:  Transgenic Res       Date:  2016-02-06       Impact factor: 2.788

Review 2.  3R measures in facilities for the production of genetically modified rodents.

Authors:  Branko Zevnik; Boris Jerchow; Thorsten Buch
Journal:  Lab Anim (NY)       Date:  2022-05-31       Impact factor: 9.667

3.  Efficient generation of germ line transmitting chimeras from C57BL/6N ES cells by aggregation with outbred host embryos.

Authors:  Marina Gertsenstein; Lauryl M J Nutter; Tammy Reid; Monica Pereira; William L Stanford; Janet Rossant; Andras Nagy
Journal:  PLoS One       Date:  2010-06-22       Impact factor: 3.240

4.  Efficiency comparison of B6(Cg)-Tyrc-2j /J and C57BL/6NTac embryos as hosts for the generation of knockout mice.

Authors:  Yu'e Ma; Lei He; Lijie Xiang; Jie Zhang; Jing Wang; Wenjing Zhu; Wenni Cao; Yichen Zhu; Man Gao; Fei Zhou; Zhiwei Liu
Journal:  Transgenic Res       Date:  2021-04-12       Impact factor: 2.788

5.  CRISPR/Cas9-Mediated Insertion of loxP Sites in the Mouse Dock7 Gene Provides an Effective Alternative to Use of Targeted Embryonic Stem Cells.

Authors:  Kathleen A Bishop; Anne Harrington; Evguenia Kouranova; Edward J Weinstein; Clifford J Rosen; Xiaoxia Cui; Lucy Liaw
Journal:  G3 (Bethesda)       Date:  2016-07-07       Impact factor: 3.154

6.  Development of a chronic kidney disease model in C57BL/6 mice with relevance to human pathology.

Authors:  Linghong Huang; Alessandra Scarpellini; Muriel Funck; Elisabetta A M Verderio; Timothy S Johnson
Journal:  Nephron Extra       Date:  2013-01-11

7.  A high-speed congenic strategy using first-wave male germ cells.

Authors:  Narumi Ogonuki; Kimiko Inoue; Michiko Hirose; Ikuo Miura; Keiji Mochida; Takahiro Sato; Nathan Mise; Kazuyuki Mekada; Atsushi Yoshiki; Kuniya Abe; Hiroki Kurihara; Shigeharu Wakana; Atsuo Ogura
Journal:  PLoS One       Date:  2009-03-31       Impact factor: 3.240

8.  C57BL/6N albino/agouti mutant mice as embryo donors for efficient germline transmission of C57BL/6 ES cells.

Authors:  Branko Zevnik; Nathalie C Uyttersprot; Ana V Perez; Gerald W M Bothe; Heidrun Kern; Gunther Kauselmann
Journal:  PLoS One       Date:  2014-03-05       Impact factor: 3.240
  8 in total

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