| Literature DB >> 18359227 |
Michele C Jetter1, James J McNally, Mark A Youngman, Mark E McDonnell, Adrienne E Dubin, Nadia Nasser, Sui-Po Zhang, Ellen E Codd, Ray W Colburn, Dennis R Stone, Michael R Brandt, Christopher M Flores, Scott L Dax.
Abstract
High throughput screening of our compound library revealed a series of N-pyridyl-3-benzamides as low micromolar agonists of the human TRPV1 receptor. Synthesis of analogs in this series led to the discovery of a series of N-quinolin-3-yl-benzamides as low nanomolar antagonists of human TRPV1.Entities:
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Year: 2008 PMID： 18359227 DOI： 10.1016/j.bmcl.2008.02.075
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823