AIMS: Our aim was to investigate whether the dynamic and static compliances differ between patients with irritable bowel syndrome (IBS) and normal subjects. MATERIALS AND METHODS: Fifty-five IBS patients (age range 20-65 years, mean age 39.0 years, 28 women and 27 men; 36 diarrhea-predominant IBS (IBS-D) patients and 19 constipation-predominant IBS (IBS-C) patients) with symptoms that fulfilled the Rome-II criteria and 21 healthy controls (age range 25-58 years, mean age 37.8 years; 11 women and ten men) were recruited. The anorectal functions, including dynamic compliance, were evaluated via barostat tests. A power exponential model was used for the evaluation of static compliance. RESULTS: There was no significant difference in dynamic compliance between the normal subjects and the IBS patients (10.3+/-3.1 and 8.9+/-2.9 mmHg, respectively, P>0.05). However, even though no significant difference was detected in the overall shape of the curve (beta; P>0.05), there were significant differences in the kappa and P (half) between the normal subjects and the IBS patients (P<0.05), respectively. When we compared the dynamic and static compliances between the IBS-C and IBS-D patients, there were no significant differences found (P>0.05). CONCLUSIONS: An exponential model provided good fit to the actual data, and there were significant differences in static compliance between the normal subjects and the IBS patients. This result can reveal the altered biomechanical properties of the gut wall in IBS patients.
AIMS: Our aim was to investigate whether the dynamic and static compliances differ between patients with irritable bowel syndrome (IBS) and normal subjects. MATERIALS AND METHODS: Fifty-five IBSpatients (age range 20-65 years, mean age 39.0 years, 28 women and 27 men; 36 diarrhea-predominant IBS (IBS-D) patients and 19 constipation-predominant IBS (IBS-C) patients) with symptoms that fulfilled the Rome-II criteria and 21 healthy controls (age range 25-58 years, mean age 37.8 years; 11 women and ten men) were recruited. The anorectal functions, including dynamic compliance, were evaluated via barostat tests. A power exponential model was used for the evaluation of static compliance. RESULTS: There was no significant difference in dynamic compliance between the normal subjects and the IBSpatients (10.3+/-3.1 and 8.9+/-2.9 mmHg, respectively, P>0.05). However, even though no significant difference was detected in the overall shape of the curve (beta; P>0.05), there were significant differences in the kappa and P (half) between the normal subjects and the IBSpatients (P<0.05), respectively. When we compared the dynamic and static compliances between the IBS-C and IBS-D patients, there were no significant differences found (P>0.05). CONCLUSIONS: An exponential model provided good fit to the actual data, and there were significant differences in static compliance between the normal subjects and the IBSpatients. This result can reveal the altered biomechanical properties of the gut wall in IBSpatients.
Authors: A E Bharucha; M Camilleri; S Haydock; I Ferber; D Burton; S Cooper; D Tompson; K Fitzpatrick; R Higgins; A R Zinsmeister Journal: Gut Date: 2000-11 Impact factor: 23.059
Authors: S A L W Vanhoutvin; F J Troost; T O C Kilkens; P J Lindsey; D M A E Jonkers; K Venema; A Masclee; R-J M Brummer Journal: J Gastroenterol Date: 2012-02-24 Impact factor: 7.527