Jennifer B Freeman1, Abbe M Garcia2, Lisa Coyne2, Chelsea Ale2, Amy Przeworski2, Michael Himle2, Scott Compton2, Henrietta L Leonard2. 1. Drs. Freeman, Garcia, Coyne, Ale, Przeworski, Himle, and Leonard are with the Bradley Hasbro Children's Research Center, Providence, RI; and Dr. Compton is with Duke University, Durham, NC.. Electronic address: Jennifer_Freeman@Brown.edu. 2. Drs. Freeman, Garcia, Coyne, Ale, Przeworski, Himle, and Leonard are with the Bradley Hasbro Children's Research Center, Providence, RI; and Dr. Compton is with Duke University, Durham, NC.
Abstract
OBJECTIVE: To examine the relative efficacy of family-based cognitive-behavioral therapy (CBT) versus family-based relaxation treatment (RT) for young children ages 5 to 8 years with obsessive-compulsive disorder (OCD). METHOD: Forty-two young children with primary OCD were randomized to receive 12 sessions of family-based CBT or family-based RT. Assessments were conducted before and after treatment by independent raters blind to treatment assignment. Primary outcomes included scores on the Children's Yale-Brown Obsessive Compulsive Scale and Clinical Global Impressions-Improvement. RESULTS: For the intent-to-treat sample, CBT was associated with a moderate treatment effect (d = 0.53), although there was not a significant difference between the groups at conventional levels. For the completer sample, CBT had a large effect (d = 0.85), and there was a significant group difference favoring CBT. In the intent-to-treat sample, 50% of children in the CBT group achieved remission as compared to 20% in the RT group. In the completer sample, 69% of children in the CBT group achieved a clinical remission compared to 20% in the RT group. CONCLUSIONS: Results indicate that children with early-onset OCD benefit from a treatment approach tailored to their developmental needs and family context. CBT was effective in reducing OCD symptoms and in helping a large number of children achieve a clinical remission.
RCT Entities:
OBJECTIVE: To examine the relative efficacy of family-based cognitive-behavioral therapy (CBT) versus family-based relaxation treatment (RT) for young children ages 5 to 8 years with obsessive-compulsive disorder (OCD). METHOD: Forty-two young children with primary OCD were randomized to receive 12 sessions of family-based CBT or family-based RT. Assessments were conducted before and after treatment by independent raters blind to treatment assignment. Primary outcomes included scores on the Children's Yale-Brown Obsessive Compulsive Scale and Clinical Global Impressions-Improvement. RESULTS: For the intent-to-treat sample, CBT was associated with a moderate treatment effect (d = 0.53), although there was not a significant difference between the groups at conventional levels. For the completer sample, CBT had a large effect (d = 0.85), and there was a significant group difference favoring CBT. In the intent-to-treat sample, 50% of children in the CBT group achieved remission as compared to 20% in the RT group. In the completer sample, 69% of children in the CBT group achieved a clinical remission compared to 20% in the RT group. CONCLUSIONS: Results indicate that children with early-onset OCD benefit from a treatment approach tailored to their developmental needs and family context. CBT was effective in reducing OCD symptoms and in helping a large number of children achieve a clinical remission.
Authors: L Scahill; M A Riddle; M McSwiggin-Hardin; S I Ort; R A King; W K Goodman; D Cicchetti; J F Leckman Journal: J Am Acad Child Adolesc Psychiatry Date: 1997-06 Impact factor: 8.829
Authors: Jennifer B Freeman; Molly L Choate-Summers; Phoebe S Moore; Abbe M Garcia; Jeffrey J Sapyta; Henrietta L Leonard; Martin E Franklin Journal: Biol Psychiatry Date: 2007-02-01 Impact factor: 13.382
Authors: M A Garvey; S J Perlmutter; A J Allen; S Hamburger; L Lougee; H L Leonard; M E Witowski; B Dubbert; S E Swedo Journal: Biol Psychiatry Date: 1999-06-15 Impact factor: 13.382
Authors: S J Perlmutter; S F Leitman; M A Garvey; S Hamburger; E Feldman; H L Leonard; S E Swedo Journal: Lancet Date: 1999-10-02 Impact factor: 79.321
Authors: B Birmaher; D A Brent; L Chiappetta; J Bridge; S Monga; M Baugher Journal: J Am Acad Child Adolesc Psychiatry Date: 1999-10 Impact factor: 8.829
Authors: Jennifer Freeman; Jeffrey Sapyta; Abbe Garcia; Scott Compton; Muniya Khanna; Chris Flessner; David FitzGerald; Christian Mauro; Rebecca Dingfelder; Kristen Benito; Julie Harrison; John Curry; Edna Foa; John March; Phoebe Moore; Martin Franklin Journal: JAMA Psychiatry Date: 2014-06 Impact factor: 21.596