OBJECTIVE: To assess the incidence and epidemiological pattern of respiratory viruses in HIV-infected patients and to evaluate their potential clinical impact. DESIGN AND METHODS: A prospective population-based cohort study was conducted at three Swiss university hospitals. Study participants were HIV-infected patients who underwent a bronchoalveolar lavage to rule out an opportunistic event. All bronchoalveolar lavage specimens were screened using a set of real-time reverse transcriptase-polymerase chain reaction assays targeting 17 different respiratory viruses. RESULTS: Between November 2003 and November 2006, 59 bronchoalveolar episodes from 55 HIV-infected patients were analysed. Eleven of 59 episodes (18.6%) were positive for at least one respiratory virus. Coronavirus OC43 was identified in three cases (27.3%) followed by influenza A in two (18.2%). Parainfluenza virus (PIV) 2, PIV 3, PIV 4, bocavirus, human rhinovirus A and human metapneumovirus were each identified in one case (9%). In the majority of these cases (63.6%) no other concomitant microorganism was isolated. CONCLUSIONS: Clinical investigation of respiratory viral infections in HIV-infected patients should not be restricted to prototype viruses and also need to target all the different family of viruses as it seems likely that these viruses contribute to pulmonary complications and morbidity in this population.
OBJECTIVE: To assess the incidence and epidemiological pattern of respiratory viruses in HIV-infectedpatients and to evaluate their potential clinical impact. DESIGN AND METHODS: A prospective population-based cohort study was conducted at three Swiss university hospitals. Study participants were HIV-infectedpatients who underwent a bronchoalveolar lavage to rule out an opportunistic event. All bronchoalveolar lavage specimens were screened using a set of real-time reverse transcriptase-polymerase chain reaction assays targeting 17 different respiratory viruses. RESULTS: Between November 2003 and November 2006, 59 bronchoalveolar episodes from 55 HIV-infectedpatients were analysed. Eleven of 59 episodes (18.6%) were positive for at least one respiratory virus. Coronavirus OC43 was identified in three cases (27.3%) followed by influenza A in two (18.2%). Parainfluenza virus (PIV) 2, PIV 3, PIV 4, bocavirus, human rhinovirus A and human metapneumovirus were each identified in one case (9%). In the majority of these cases (63.6%) no other concomitant microorganism was isolated. CONCLUSIONS: Clinical investigation of respiratory viral infections in HIV-infectedpatients should not be restricted to prototype viruses and also need to target all the different family of viruses as it seems likely that these viruses contribute to pulmonary complications and morbidity in this population.
Authors: Verena Schildgen; Bernadette van den Hoogen; Ron Fouchier; Ralph A Tripp; Rene Alvarez; Catherine Manoha; John Williams; Oliver Schildgen Journal: Clin Microbiol Rev Date: 2011-10 Impact factor: 26.132
Authors: Jutte J C de Vries; Robbert G M Bredius; Patrick F van Rheenen; Frans J W Smiers; Elisabeth H Schölvinck; Ann C T M Vossen; Eric C J Claas; Hubert G M Niesters Journal: J Clin Microbiol Date: 2009-02-04 Impact factor: 5.948
Authors: Kate V Atkinson; Lisa A Bishop; Glenn Rhodes; Nicolas Salez; Neil R McEwan; Matthew J Hegarty; Julie Robey; Nicola Harding; Simon Wetherell; Robert M Lauder; Roger W Pickup; Mark Wilkinson; Derek Gatherer Journal: Genome Announc Date: 2017-03-23
Authors: Marta C Nunes; Zachary Kuschner; Zelda Rabede; Richard Madimabe; Nadia Van Niekerk; Jackie Moloi; Locadiah Kuwanda; John W Rossen; Keith P Klugman; Peter V Adrian; Shabir A Madhi Journal: PLoS One Date: 2014-02-03 Impact factor: 3.240
Authors: Silvana Augusta Rodrigues Portes; Filipe Anibal Carvalho-Costa; Monica Simões Rocha; Tulio Machado Fumian; Adriana Gonçalves Maranhão; Rosane Maria de Assis; Maria da Penha Trindade Pinheiro Xavier; Myrna Santos Rocha; Marize Pereira Miagostovich; José Paulo Gagliardi Leite; Eduardo de Mello Volotão Journal: PLoS One Date: 2017-08-30 Impact factor: 3.240