Literature DB >> 1835658

Serum dehydroepiandrosterone sulfate in Alzheimer's disease and in multi-infarct dementia.

B Näsman1, T Olsson, T Bäckström, S Eriksson, K Grankvist, M Viitanen, G Bucht.   

Abstract

Circulating levels of dehydroepiandrosterone sulfate (DHEAS) and cortisol were studied in 86 patients with dementia; 45 with Alzheimer's disease and 41 with multi-infarct dementia. Compared to an elderly control group, after adjustment for age and sex, patients with Alzheimer's disease were found to have lower serum levels of DHEAS. We found a covariation between serum albumin and DHEAS levels, which may be of importance regarding peripheral hormone concentration in patients with dementia. These findings may provide evidence for a role of DHEAS in amnestic disorder in humans, either reflecting or contributing to the course of dementing diseases.

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Year:  1991        PMID： 1835658     DOI： 10.1016/0006-3223(91)90013-c

Source DB:  PubMed          Journal:  Biol Psychiatry        ISSN： 0006-3223            Impact factor:   13.382


  17 in total

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