| Literature DB >> 18356253 |
I Reuter1, Y F Tai, N Pavese, K R Chaudhuri, S Mason, C E Polkey, C Clough, D J Brooks, R A Barker, P Piccini.
Abstract
Two patients with moderate Huntington's disease (HD) received bilateral fetal striatal allografts. One patient demonstrated, for the first time, increased striatal D2 receptor binding, evident with 11C-raclopride positron emission tomography, and prolonged clinical improvement over 5 years, suggesting long term survival and efficacy of the graft. The other patient did not improve clinically or radiologically. Our results indicate that striatal transplantation in HD may be beneficial but further studies are needed to confirm this.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18356253 DOI： 10.1136/jnnp.2007.142380
Source DB: PubMed Journal: J Neurol Neurosurg Psychiatry ISSN： 0022-3050 Impact factor: 10.154