I Bone1, L Belton, A S Walker, J Darbyshire. 1. Department of Medical and Cardiovascular Studies, Western Infirmary, Glasgow, UK. gcl136@clinmed.gla.ac.uk
Abstract
UNLABELLED: BACKGROUND, PURPOSE AND METHODS: This observational study assessed the effect of continuous intraventricular infusion of pentosan polysulphate (PPS) in seven patients at different clinical centres in the UK. RESULTS: Complications of intraventricular catheterization were frequent. PPS was well-tolerated over a wide dose range (11-110 microg/kg/day) during the 6-month study. Four patients were assessed for the entire study period: one remained stable, two showed minimal deterioration and one progressed significantly. CONCLUSION: Mean survival of all patients was longer than reported values for natural history of specific prion disorders. Possible reasons for these findings are explored.
UNLABELLED: BACKGROUND, PURPOSE AND METHODS: This observational study assessed the effect of continuous intraventricular infusion of pentosan polysulphate (PPS) in seven patients at different clinical centres in the UK. RESULTS: Complications of intraventricular catheterization were frequent. PPS was well-tolerated over a wide dose range (11-110 microg/kg/day) during the 6-month study. Four patients were assessed for the entire study period: one remained stable, two showed minimal deterioration and one progressed significantly. CONCLUSION: Mean survival of all patients was longer than reported values for natural history of specific prion disorders. Possible reasons for these findings are explored.
Authors: S Mead; M Ranopa; G S Gopalakrishnan; A G B Thompson; P Rudge; S Wroe; A Kennedy; F Hudson; A MacKay; J H Darbyshire; J Collinge; A S Walker Journal: Neurology Date: 2011-10-19 Impact factor: 9.910
Authors: Victoria A Lawson; Brooke Lumicisi; Jeremy Welton; Dorothy Machalek; Katrina Gouramanis; Helen M Klemm; James D Stewart; Colin L Masters; David E Hoke; Steven J Collins; Andrew F Hill Journal: PLoS One Date: 2010-08-23 Impact factor: 3.240