BACKGROUND: Although antidepressant drugs (ATD) are frequently prescribed to patients with Alzheimer's disease (AD), their effect on cognitive status has been only rarely assessed. METHODS: The impact of depressive symptoms and ATD on cognitive status was retrospectively assessed in 72 older AD outpatients with mild-to-moderate cognitive impairment, treated with cholinesterase inhibitors, over a 9-month follow-up. RESULTS: Compared to subjects without baseline depressive symptoms, those with symptoms who were continuously treated with ATD had less cognitive decline; those never treated, or not continuously treated despite baseline symptoms, had an intermediate trend. Such a protective action of ATD was, at least in part, independent of their action on depressive symptoms. CONCLUSION: These observations suggest that ATD may reduce cognitive decline in depressed older AD patients. (c) 2008 S. Karger AG, Basel.
BACKGROUND: Although antidepressant drugs (ATD) are frequently prescribed to patients with Alzheimer's disease (AD), their effect on cognitive status has been only rarely assessed. METHODS: The impact of depressive symptoms and ATD on cognitive status was retrospectively assessed in 72 older AD outpatients with mild-to-moderate cognitive impairment, treated with cholinesterase inhibitors, over a 9-month follow-up. RESULTS: Compared to subjects without baseline depressive symptoms, those with symptoms who were continuously treated with ATD had less cognitive decline; those never treated, or not continuously treated despite baseline symptoms, had an intermediate trend. Such a protective action of ATD was, at least in part, independent of their action on depressive symptoms. CONCLUSION: These observations suggest that ATD may reduce cognitive decline in depressed older ADpatients. (c) 2008 S. Karger AG, Basel.
Authors: Joseph S Goveas; Patricia E Hogan; Jane M Kotchen; Jordan W Smoller; Natalie L Denburg; JoAnn E Manson; Aruna Tummala; W Jerry Mysiw; Judith K Ockene; Nancy F Woods; Mark A Espeland; Sylvia Wassertheil-Smoller Journal: Int Psychogeriatr Date: 2012-02-03 Impact factor: 3.878
Authors: Saikat Chakraborty; Jack C Lennon; Sridhar A Malkaram; Yan Zeng; Daniel W Fisher; Hongxin Dong Journal: Neurosci Lett Date: 2019-04-01 Impact factor: 3.046
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