Literature DB >> 1835386

Scatter factor from human embryonic lung fibroblasts is probably identical to hepatocyte growth factor.

T Konishi1, T Takehara, T Tsuji, K Ohsato, K Matsumoto, T Nakamura.   

Abstract

Human embryonic lung fibroblasts (MRC5) produced scatter factor which enhanced motility of Madin-Darby canine kidney (MDCK) epithelial cells and a factor which stimulates DNA synthesis of adult rat hepatocytes in primary culture. These activities were both completely neutralized by antibody against human hepatocyte growth factor (HGF). Human recombinant HGF induced a marked scattering of MDCK cells. Moreover, MRC5 cells highly expressed 6kb mRNA which hybridized with HGF cDNA probe and scatter factor cDNA cloned from the MRC5 cDNA library had the same sequence as that of HGF cDNA from human leukocytes. These results indicate that HGF possesses scatter factor activity and the scatter factor derived from the MRC5 cells is probably identical to HGF.

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Year:  1991        PMID： 1835386     DOI： 10.1016/s0006-291x(05)81131-3

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  19 in total

1.  The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells.

Authors:  S Koochekpour; M Jeffers; P H Wang; C Gong; G A Taylor; L M Roessler; R Stearman; J R Vasselli; W G Stetler-Stevenson; W G Kaelin; W M Linehan; R D Klausner; J R Gnarra; G F Vande Woude
Journal:  Mol Cell Biol       Date:  1999-09       Impact factor: 4.272

2.  MicroRNA-24 regulates the processing of latent TGFβ1 during cyclic mechanical stress in human trabecular meshwork cells through direct targeting of FURIN.

Authors:  Coralia Luna; Guorong Li; Jianming Qiu; David L Epstein; Pedro Gonzalez
Journal:  J Cell Physiol       Date:  2011-05       Impact factor: 6.384

3.  Hepatocyte growth factor prevents acute renal failure and accelerates renal regeneration in mice.

Authors:  K Kawaida; K Matsumoto; H Shimazu; T Nakamura
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-10       Impact factor: 11.205

4.  E-cadherin dis-engagement activates the Rap1 GTPase.

Authors:  Sirisha Asuri; Jingliang Yan; Nivanka C Paranavitana; Lawrence A Quilliam
Journal:  J Cell Biochem       Date:  2008-11-01       Impact factor: 4.429

5.  Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor.

Authors:  S Rong; M Bodescot; D Blair; J Dunn; T Nakamura; K Mizuno; M Park; A Chan; S Aaronson; G F Vande Woude
Journal:  Mol Cell Biol       Date:  1992-11       Impact factor: 4.272

6.  Identification and characterization of "injurin," an inducer of expression of the gene for hepatocyte growth factor.

Authors:  K Matsumoto; H Tajima; M Hamanoue; S Kohno; T Kinoshita; T Nakamura
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-01       Impact factor: 11.205

7.  Regulation of spreading and growth of colon cancer cells by hepatocyte growth factor.

Authors:  W G Jiang; D Lloyds; M C Puntis; T Nakamura; M B Hallett
Journal:  Clin Exp Metastasis       Date:  1993-05       Impact factor: 5.150

8.  Effect of hepatocyte growth factor/scatter factor and other growth factors on motility and morphology of non-tumorigenic and tumor cells.

Authors:  Y Li; M M Bhargava; A Joseph; L Jin; E M Rosen; I D Goldberg
Journal:  In Vitro Cell Dev Biol Anim       Date:  1994-02       Impact factor: 2.416

9.  Stimulative effect of non-parenchymal liver cells on ability of tyrosine aminotransferase induction in hepatocytes.

Authors:  K Yagi; N Suenobu; M Serada; K Tsuda; A Kondoh; Y Miura
Journal:  Cytotechnology       Date:  1992       Impact factor: 2.058

10.  Expression of hepatocyte growth factor and c-met genes during hepatic differentiation and liver development in the rat.

Authors:  Z Hu; R P Evarts; K Fujio; E R Marsden; S S Thorgeirsson
Journal:  Am J Pathol       Date:  1993-06       Impact factor: 4.307
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