Literature DB >> 18353695

Clostridium perfringens toxin genotypes in the feces of healthy North Americans.

Robert J Carman1, Sameera Sayeed, Jihong Li, Christopher W Genheimer, Megan F Hiltonsmith, Tracy D Wilkins, Bruce A McClane.   

Abstract

We investigated the frequency of Clostridium perfringens in the normal fecal flora of healthy North Americans. About half of 43 subjects were colonized with C. perfringens at levels of approximately 10(6)cfu/g feces. Only type A strains were recovered. Spores sometimes outnumbered vegetative cells. Several genotypes were found. Some donors carried two genotypes, some only one. We found no alpha, beta2 or enterotoxin in the stools of any donors. Though some isolates carried toxin genes (e.g. cpe and cpb2) on plasmids, we saw no indication that healthy humans are the reservoir for the chromosomally-borne cpe recovered from cases of C. perfringens food poisoning.

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Year:  2008        PMID： 18353695      PMCID： PMC2444017          DOI： 10.1016/j.anaerobe.2008.01.003

Source DB:  PubMed          Journal:  Anaerobe        ISSN： 1075-9964            Impact factor:   3.331


  42 in total

1.  Similar frequency of detection of Clostridium perfringens enterotoxin and Clostridium difficile toxins in patients with antibiotic-associated diarrhea.

Authors:  C Abrahao; R J Carman; H Hahn; O Liesenfeld
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2001-09       Impact factor: 3.267

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Journal:  Rev Latinoam Microbiol       Date:  1975 Oct-Dec

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Journal:  Lancet       Date:  1984-02-11       Impact factor: 79.321

4.  Complete sequencing and diversity analysis of the enterotoxin-encoding plasmids in Clostridium perfringens type A non-food-borne human gastrointestinal disease isolates.

Authors:  Kazuaki Miyamoto; Derek J Fisher; Jihong Li; Sameera Sayeed; Shigeru Akimoto; Bruce A McClane
Journal:  J Bacteriol       Date:  2006-02       Impact factor: 3.490

5.  Multiplex PCR genotyping assay that distinguishes between isolates of Clostridium perfringens type A carrying a chromosomal enterotoxin gene (cpe) locus, a plasmid cpe locus with an IS1470-like sequence, or a plasmid cpe locus with an IS1151 sequence.

Authors:  Kazuaki Miyamoto; Qiyi Wen; Bruce A McClane
Journal:  J Clin Microbiol       Date:  2004-04       Impact factor: 5.948

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Journal:  J Clin Microbiol       Date:  1983-03       Impact factor: 5.948

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Journal:  J Clin Microbiol       Date:  1994-10       Impact factor: 5.948

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Journal:  Jpn J Microbiol       Date:  1976-10

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Journal:  Mol Microbiol       Date:  1995-02       Impact factor: 3.501
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  30 in total

1.  NanI Sialidase Can Support the Growth and Survival of Clostridium perfringens Strain F4969 in the Presence of Sialyated Host Macromolecules (Mucin) or Caco-2 Cells.

Authors:  Jihong Li; Bruce A McClane
Journal:  Infect Immun       Date:  2018-01-22       Impact factor: 3.441

2.  Genomic diversity of Clostridium perfringens strains isolated from food and human sources.

Authors:  A Afshari; A Jamshidi; J Razmyar; M Rad
Journal:  Iran J Vet Res       Date:  2016       Impact factor: 1.376

3.  Effect of Lactobacillus fermentum on beta2 toxin production by Clostridium perfringens.

Authors:  Janneke G Allaart; Alphons J A M van Asten; Johannes C M Vernooij; Andrea Gröne
Journal:  Appl Environ Microbiol       Date:  2011-05-20       Impact factor: 4.792

4.  Native or Proteolytically Activated NanI Sialidase Enhances the Binding and Cytotoxic Activity of Clostridium perfringens Enterotoxin and Beta Toxin.

Authors:  James R Theoret; Jihong Li; Mauricio A Navarro; Jorge P Garcia; Francisco A Uzal; Bruce A McClane
Journal:  Infect Immun       Date:  2017-12-19       Impact factor: 3.441

5.  Freshwater suspended sediments and sewage are reservoirs for enterotoxin-positive Clostridium perfringens.

Authors:  Sabrina R Mueller-Spitz; Lisa B Stewart; J Val Klump; Sandra L McLellan
Journal:  Appl Environ Microbiol       Date:  2010-06-25       Impact factor: 4.792

6.  Contributions of NanI sialidase to Caco-2 cell adherence by Clostridium perfringens type A and C strains causing human intestinal disease.

Authors:  Jihong Li; Bruce A McClane
Journal:  Infect Immun       Date:  2014-08-18       Impact factor: 3.441

7.  Determination of Genomic Epidemiology of Historical Clostridium perfringens Outbreaks in New York State by Use of Two Web-Based Platforms: National Center for Biotechnology Information Pathogen Detection and FDA GalaxyTrakr.

Authors:  Jaclyn Carey; Jocelyn Cole; Sai Laxmi Gubbala Venkata; Hannah Hoyt; Lisa Mingle; David Nicholas; Kimberlee A Musser; William J Wolfgang
Journal:  J Clin Microbiol       Date:  2021-01-21       Impact factor: 5.948

8.  Lytic enzyme discovery through multigenomic sequence analysis in Clostridium perfringens.

Authors:  Jonathan E Schmitz; Maria Cristina Ossiprandi; Kareem R Rumah; Vincent A Fischetti
Journal:  Appl Microbiol Biotechnol       Date:  2010-11-18       Impact factor: 4.813

9.  Use of an EZ-Tn5-based random mutagenesis system to identify a novel toxin regulatory locus in Clostridium perfringens strain 13.

Authors:  Jorge E Vidal; Jianming Chen; Jihong Li; Bruce A McClane
Journal:  PLoS One       Date:  2009-07-14       Impact factor: 3.240

10.  Type IV pili and the CcpA protein are needed for maximal biofilm formation by the gram-positive anaerobic pathogen Clostridium perfringens.

Authors:  John J Varga; Blair Therit; Stephen B Melville
Journal:  Infect Immun       Date:  2008-09-02       Impact factor: 3.441
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