| Literature DB >> 18353644 |
Atma P Dwivedi1, Shailesh Kumar, Vandana Varshney, Amar B Singh, Arvind K Srivastava, Devi P Sahu.
Abstract
A series of novel N-acyl-2-arylethylamines and N-acyl-3-coumarylamines were synthesized and evaluated for their antihyperglycemic activity. Compounds 3g and 6d exhibited lowering of postprandial plasma glucose by 30.7%, 23.3% in SLM and 25.6%, 25.4% in STZ models respectively which is significant compared to metformin and glybenclamide. Other compounds exhibited moderate to good activity ranging from 19.5% to 32.8% in SLM and 3.26% to 25.4% in STZ models.Entities:
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Year: 2008 PMID： 18353644 DOI： 10.1016/j.bmcl.2008.03.003
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823