| Literature DB >> 18353639 |
Setsuya Sasho1, Takashi Seishi, Mariko Kawamura, Ryo Hirose, Shinichiro Toki, Jun-ich Shimada.
Abstract
Novel diamine derivatives containing imidazolidinylidene propanedinitrile were synthesized and evaluated for histamine H(3) receptor-binding affinities. High-affinity ligands 3d, 3k, and 3n showed potent H(3) receptor antagonism and excellent selectivity over human H(1), H(2) and H(4) receptors.Entities:
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Year: 2008 PMID： 18353639 DOI： 10.1016/j.bmcl.2008.03.006
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823